Genetic effects on variation in red-blood-cell folate in adults: Implications for the familial aggregation of neural tube defects

American Journal of Human Genetics

Volumn 60, Issue 2, 1997, Pages 433-438

  Mitchell, Laura E ^a   Duffy, David L ^b   Duffy, Patrick ^c   Bellingham, Glenda ^c   Martin, Nicholas G ^b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID;

ARTICLE; DNA SYNTHESIS INHIBITION; ERYTHROCYTE AGGREGATION; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; NEURAL TUBE DEFECT; PHENOTYPE; PRIORITY JOURNAL; TANDEM REPEAT; ZYGOSITY;

ADULT; AGE FACTORS; BLOOD SPECIMEN COLLECTION; ERYTHROCYTES; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MODELS, GENETIC; MODELS, STATISTICAL; NEURAL TUBE DEFECTS; ODDS RATIO; RISK FACTORS; SEX CHARACTERISTICS; STATISTICS, NONPARAMETRIC; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 0031038093     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Aalen OO (1991) Modelling the influence of risk factors on familial aggregation of disease. Biometrics 47:933-945
2. Boushey CJ, Beresford SSA, Omenn GS, Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intake. JAMA 274:1049-1057
3. Butterworth CE (1991) Folate deficiency in cancer. In: Bendich A, Butterworth CE (eds) Micronutrients in health and disease prevention. Marcel Dekker, New York, pp 165-183
4. Cowchock S, Ainbender E, Prescott G, Crandall B, Lau L, Heller R, Muir WA, et al (1980) The recurrence risk for neural tube defects in the United States: a collaborative study. Am J Med Genet 5:309-314
5. Cragan JD, Roberts HE, Edmonds LD, Khoury MJ, Kirby RS, Shaw GM, Velie EM, et al (1995) Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis - United States, 1985-1994. MMWR 44:1-13
6. Czeizel AE (1996) Reduction of urinary tract and cardiovascular defects by periconceptional vitamin supplementation. Am J Med Genet 62:179-183
7. Czeizel AE, Dudas I (1992) Prevention of first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327:1832-1835
8. Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM (1995) Folate levels and neural tube defects: implications for prevention. JAMA 274:1698-1702
9. Davis RE (1986) Clinical chemistry of folic acid. Adv Clin Chem 25:233-294
10. Hopper JL, Carlin JB (1992) Familial aggregation of a disease consequent upon correlation between relatives in a risk factor measured on a continuous scale. Am J Epidemiol 136: 1138-1147
11. Lange K, Weeks D, Boehnke M (1988) Programs for pedigree analysis: MENDEL, FISHER and dGENE. Genet Epidemiol 55:471-472
12. Leek I (1977) Folates and the fetus. Lancet 1:1099-1100
13. Li DK, Daling JR, Mueller BA, Hickok DE, Fantel AG, Weiss NS (1995) Periconceptional multivitamin use in relation to the risk of congenital urinary tract anomalies. Epidemiology 6:212-218
14. Mitchell LE, Duffy DL, Martin NG (1994) Evidence for familial effects on variation in red blood cell folate: implications for the familial aggregation of neural tube defects. Am J Hum Genet Suppl 55:A47
15. MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet 338:131-137
16. Rosenblatt DS (1989) Inherited disorders of folate metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic basis of inherited disease, 6th ed. McGraw-Hill, New York, pp 2049-2064
17. SAS Institute (1991) The SAS system, version 6.10. SAS Institute, Cary NC
18. Scott JM, Weir DG, Molloy A, McPartlin J, Daly L, Kirke P (1994) Folie acid metabolism and mechanisms of neural tube defects. Ciba Foundation Symposium. Vol 181. John Wiley, Chichester, England
19. Shaw GM, Lammer EJ, Wasserman CR, O'Malley CD, Tolarova MM (1995) Risk of orofacial clefts in women using multivitamins containing folic acid periconceptionally. Lancet 346:393-396
20. Shaw GM, Wasserman CR, O'Malley CD (1994) Periconceptional vitamin use and reduced risk for conotruncal and limb defects in California. Teratology 49:372
21. Treloar SA, Martin NG, Dennerstein L, Raphael B, Heath AC (1992) Pathways to hysterectomy: insights from longitudinal twin research. Am J Obstet Gynecol 167:82-88
22. Wald N (1993) Folic acid and the prevention of neural tube defects. Ann NY Acad Sci 678:112-129
23. Zackai EM, Spielman RS, Mellman RJ, Ames M, Bodurtha J (1978) The risk of neural tube defects to first cousins of affected individuals. In: Crandall BF, Brazier MZ (eds) The prevention of neural tube defects: the role of alpha-fetoprotein. Academic Press, New York, pp 99-102