Inducible overexpression of Bak sensitizes HCC-9204 cells to apoptosis induced by doxorubicin

Acta Pharmacologica Sinica

Volumn 21, Issue 9, 2000, Pages 769-776

  Li, J ^a   Wang, W L ^a   Yang, X K ^a   Yu, X X ^a   Hou, Y D ^a   Zhang, J ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bak genes; Doxorubicin; Hepatocellular carcinoma; Vinorelbine

Indexed keywords

DOXORUBICIN; NAVELBINE; PROTEIN BAK;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL SURVIVAL; CELL VIABILITY; CLONOGENESIS; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG SENSITIVITY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MORPHOLOGY; NICK END LABELING;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; DOXORUBICIN; GENE EXPRESSION; HUMAN; LIVER NEOPLASMS; MEMBRANE PROTEINS; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0033804575     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak
2. A conserved domain in Bak, distinct from BH1 and BH2 mediates cell death and protein binding functions
3. Establishment of a human hepatocellular carcinoma cell line HCC-9204 and its characteristics
4. Induction of apoptosis by the Bcl-2 homologue Bak
5. TUNEL assay of apoptosis in human hepatocellular carcinoma under laser confocal microscope
6. The morphological and spectral phenotype of apoptosis in HeLa cells varies following exposure to UV-C and the addition of inhibitors of ICE and CPP32
7. Detection of fragmented DNA in apoptotic cells embedded in LR white: A combined histochemical (LM) and ultrastructural (EM) study
8. Apoptosis, p53, and tumor cell sensitivity to anticancer agents
9. Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7
10. Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
11. Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents
12. What is an apoptotic index measuring? A commentary