Evidence for an amphipathicity independent cellular uptake of amphipathic cell-penetrating peptides

European Journal of Biochemistry

Volumn 267, Issue 19, 2000, Pages 6043-6050

  Scheller, Anne ^a   Wiesner, Burkhard ^a   Melzig, Matthias ^b   Bienert, Michael ^a   Oehlke, Johannes ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Amphipathic peptides; Cell penetrating peptides; Cellular uptake; Confocal laser scanning microscopy

Indexed keywords

CELL PROTEIN; PEPTIDE DERIVATIVE;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SOLUBILITY;

ANIMALIA;

EID: 0033802715     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01681.x     Document Type: Article

References (28)

1. The third helix of the Antennapedia homeodomain translocates through biological membranes
2. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
3. Transfection of mitochondria: Strategy towards a gene therapy of mitochondrial DNA diseases
4. Cell penetration by transportan
5. Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide
6. Tat-mediated delivery of heterologous proteins into cells
7. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
8. Cell-penetrating peptides
9. Nonendocytic, amphipathicity dependent cellular uptake of helical model peptides
10. Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically
11. Structural requirements for cellular uptake of alpha-helical amphipathic peptides
12. The retro-inverso form of a homeobox-derived short peptide is rapidly internalised by cultured neurones: A new basis for an efficient intracellular delivery system
13. Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent
14. Conformational and topological requirements of cell-permeable peptide function
15. Conformations of primary amphipathic carrier peptides in membrane mimicking environments
16. Interactions of primary amphipathic vector peptides with membranes. Conformational consequences and influence on cellular localization
17. Getting hydrophilic compounds into cells: Lessons from homeopeptides
18. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
19. Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells
20. Evidence for extensive and non-specific translocation of oligopeptides across plasma membranes of mammalian cells
21. Mechanism of peptide-induced mast cell degranulation - Translocation and patch-clamp studies
22. In vitro cultivation and behavior of aortic endothelium cells in a low serum culture medium
23. Aquaporin-2 expression in primary cultured rat inner medullary collecting duct cells
24. Genetic engineering of proteins with cell membrane permeability
25. Intercellular delivery of functional p53 by the herpesvirus protein VP22
26. Nuclear translocation of human angiogenin in cultured human umbilical artery endothelial cells is microtubule and lysosome independent
27. Characterisation of membrane oligonucleotide-binding proteins and oligonucleotide uptake in keratinocytes
28. Glutathione permeability of CFTR