Selective potentiating effect of RS14203 on a serotoninergic pathway in anesthetized rats

Canadian Journal of Physiology and Pharmacology

Volumn 78, Issue 9, 2000, Pages 708-713

  Savoie, C ^a   Chan, C C ^a   Rodger, I W ^a   Robichaud, A ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Bradycardia; Emesis; PDE4 inhibitors; Vagal afferent and efferent fibres; Von Bezold Jarisch reflex

Indexed keywords

2 METHYLSEROTONIN; CT 2450; N [4 [1 (3 CYCLOPENTYLOXY 4 METHOXYPHENYL) 2 (4 PYRIDYL)ETHYL]PHENYL]N' ETHYLUREA; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; RS 14203; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EFFERENT NERVE; ELECTROSTIMULATION; EXPERIMENTAL MODEL; INFLAMMATION; LUNG DISEASE; NAUSEA; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SEROTONINERGIC TRANSMISSION; VAGUS NERVE; VAGUS REFLEX; VOMITING;

EID: 0033802693     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y00-046     Document Type: Article

References (34)

1. The physiology of emesis induced by anti-cancer therapy
2. Inhibition of nitric oxide synthase causes profound enhancement of the Bezold-Jarisch reflex
3. Fos expression in ferret dorsal vagal complex after peripheral emetic stimuli
4. 3 receptors
5. 3 receptor antagonist properties of ICS 250-930 GR38032F and zacopride
6. 3H]rolipram binding activity and their relationship to emetic behavior in the ferret
7. 3 receptor antagonist, in vivo
8. The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects
9. Emetic, central nervous system and pulmonary activities of rolipram in the dog
10. Clinical effects of neurotropic selective cAMP phosphodiesterase inhibitor rolipram in depressed patients: Global evaluation of the preliminary reports
11. Pharmacokinetically governed design of animal toxicity studies of a new antidepressant drug
12. Brain stem projections of sensory and motor components of the vagus complex in the cat
13. The history of the Bezold-Jarisch Effect
14. 3 receptor agonism may be responsible for the emetic effects of zacopride in the ferret
15. Volunteer models for predicting antiemetic activity of 5-HT3-receptor antagonists
16. The safety and tolerability of Ariflo(TM) (SB207499), a novel and selective phosphodiesterase 4 inhibitor, in healthy male volunteers
17. SB207499 (Ariflo(TM)), a second-generation, selective oral phosphodiesterase type 4 (PDE4) inhibitor, attenuates exercise induced bronchoconstriction in patients with asthma
18. The effects of theophylline on airway inflammation
19. The effect of theophylline and enprofylline on allergen induced bronchoconstriction
20. Effects of enprofylline and theophylline may show the role of adenosine
21. Characterization of CHO-KI ceils stably expressing PDE-IV enzymes. Whole-cell cAMP determinations vs. broken-cell enzymatic assays
22. 3 receptors in emesis in the ferret
23. 3 receptors
24. Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs
25. Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret
26. Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: Potential clinical importance of BRL 24924
27. Involvement of NK1 and NK2 receptors in pulmonary responses by non-adrenergic, non-cholinergic vagal stimulation in guinea pigs
28. Cardiovascular effects form stimulation of 5-hydroxytryptamine receptors
29. A canine model for determination of the therapeutic index of cytokine inhibitors
30. 3 receptor antagonist efficacy in radiation-induced emesis
31. 3 receptor antagonist
32. Medullary pathway of the Bezold-Jarisch reflex in the rat
33. Excitatory amino acid receptors in the caudal ventrolateral medulla mediate a vagal cardiopulmonary reflex in the rat