Inhibition of cytokine release by and cardiac effects of type IV phosphodiesterase inhibition in early, profound endotoxaemia in vivo

Clinical and Experimental Pharmacology and Physiology

Volumn 27, Issue 10, 2000, Pages 787-792

  Tofovic, Stevan P ^a   Zacharia, Lefteris C ^a   Carcillo, Joseph A ^a   Jackson, Edwin K ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Adrenergic agonists; Cytokines; Endotoxin; Sepsis; Ventricular function

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; CATECHOLAMINE; DIMETHYL SULFOXIDE; ENDOTOXIN; INTERLEUKIN 1BETA; PHOSPHODIESTERASE IV INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTOXEMIA; ENZYME INHIBITION; ESCHERICHIA COLI; HEART PERFORMANCE; KIDNEY FUNCTION; MALE; NONHUMAN; RAT;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; ANIMALS; CATECHOLAMINES; ENDOTOXEMIA; ESCHERICHIA COLI; HEART; HEMODYNAMIC PROCESSES; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MALE; MYOCARDIUM; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RENIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033798831     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2000.03332.x     Document Type: Article

References (35)

1. Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry, and function
2. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
3. Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney
4. The specific phosphodiesterase inhibitor loripram suppresses tumor necrosis factor-α production by human mononuclear cells
5. Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by loripram, a specific phosphodiesterase IV inhibitor
6. Differential regulation of human monocyte-derived TNFα and IL- 1β by type IV cAMP-phosphodiesterase inhibitors
7. Cytokine study in allergy and asthma
8. Asthma and airway inflammation: Potential anti-inflammatory activities of phosphodiesterase inhibitors
9. Anti-inflammatory effects of the novel phosphodiesterase IV inhibitor RP 73401
10. PDE isoenzymes as targets for anti-asthma drugs
11. Therapeutic intervention in a rat model of ARDS: IV. Phosphodiesterase IV inhibition
12. Inhibition of type IV phosphodiesterase by RO20-12724 attenuates endotoxin-induced acute renal failure
13. Treatment with the type IV phosphodiesterase inhibitor RO 20-12724 protects renal and mesenteric blood flow in endotoxemic rats treated with norepinephrine
14. Effects of type IV phosphodiesterase inhibition on cardiac function in the presence and absence of catecholamines
15. Central effects of caffeine on renal renin secretion and norepinephrine spillover
16. Depressed function of isolated hearts from hyperdynamic, septic rats
17. The effects of in vivo endotoxin on myocardial function in vitro
18. Tumor necrosis factor-α induces a biphasic effect on myocardial contractility in conscious dogs
19. TNF-α and myocardial depression in endotoxin rats: Temporal discordance of an obligatory relationship
20. Effects of an adenosine deaminase inhibitor (EHNA) and caffeine on endotoxin-induced release of cytokines and heart performance changes in vivo in rats
21. Effects of caridotonic quinoline derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: Comparison of rolipram, RO 20-1724, milrinone, and isobutyl-methylxanthine
22. The relative efficiency of beta adrenoceptor coupling to myocardial inotropy and diastolic relaxation: Organ-selective treatment for diastolic dysfunction
23. Roles of the splenic cytokines and arachidonic acid metabolites in severe hepatic injury after lipopolysaccharide injection in chronically alcohol-fed rats
24. Temporal cascade of plasma level surges in ACTH, corticosterone, and cytokines in endotoxin-challenged rats
25. Leukocyte adhesion molecules in the liver and plasma cytokine levels in endotoxin-induced rat liver injury
26. Comparison of the efficacy of pentoxifylline and albifyllin (HWA 138) on endotoxin-induced cytokine production, coagulation disturbances, and mortality
27. Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N-tert-butylnitrone (PBN)
28. The effects of antiinflammatory and antiallergic drugs on cytokine release after stimulation of human whole blood by lipopolysaccharide and zymosan A
29. Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation
30. Effects of cAMP-phosphodiesterase isozyme inhibitor on cytokine production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells
31. Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors
32. Regulation of tumor necrosis factor production by adrenal hormones in vivo: Insights into the antiinflammatory activity of rolipram
33. 4) inhibitor CP-80 633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice: Effects of adrenalectomy
34. Potentiation of cyclic AMP mediated corticotropin (ACTH) release by denbufylline in vivo and in vitro
35. Stimulation of renin secretion by the phosphodiesterase IV inhibitor rolipram