Influence of T-type Ca2+ (mibefradil) and Cl- (indanyloxyacetic acid 94) channel antagonists on α1-adrenoceptor mediated contractions in rat aorta

Canadian Journal of Physiology and Pharmacology

Volumn 78, Issue 9, 2000, Pages 714-720

  Duggan, J A ^a   Tabrizchi, R ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Cl channels; Isolated aortic rings; L type Ca2+ channel; T type Ca2+ channels

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CHLORIDE CHANNEL; CIRAZOLINE; GLYCOLIC ACID DERIVATIVE; INDANYLOXYACETIC ACID 94; MIBEFRADIL; NIFEDIPINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR RING;

EID: 0033798064     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y00-049     Document Type: Article

References (36)

1. 2+ and high-barium solution
2. - currents activated by noradrenaline in rabbit ear artery cells
3. 2+ channels in vascular muscle cells isolated from rat mesenteric arteries: Modulation by dihydropyridine drugs
4. 2+ channels in cardiac muscle, vascular muscle, and neurons
5. 2+ channels in single smooth muscle cells from rabbit ear artery studied with whole-cell and single-channel recordings
6. 1-Adrenoceptor-induced contractility in rat aorta is mediated by the α(1D) subtype
7. Mechanism of action of α-adrenoceptor activation in single cells freshly dissociated from the rabbit portal vein
8. Membrane ionic mechanisms activated by noradrenaline in cells isolated from the rabbit portal vein
9. - channel blockade on rat renal arteriolar contractile responses to angiotensin II
10. α-Methylnoradrenaline-induced contractions in rat aorta are mediated via α(1D)-adrenoceptors
11. Effect of niflumic acid on noradrenaline-induced contractions of he rat aorta
12. Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat
13. 2+ antagonist
14. RS-17053 (N-[2-(cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in human prostate: Implications for adrenoceptor classification
15. - and potassium currents in rabbit portal vein smooth muscle cells
16. Properties of a Cl-current activated by cell swelling in rabbit portal vein vascular smooth muscle cells
17. Effects of niflumic on α1-adrenoceptor-induced vasoconstriction in mesenteric artery in vitro and in vivo in two-kidney one-clip hypertensive rats
18. - currents in smooth muscle cells from the rabbit portal vein
19. - and potassium currents in smooth muscle cells from rabbit portal vein
20. - channel in smooth-muscle cells isolated from human mesenteric artery
21. - channels by organic and inorganic blockers in vascular smooth muscle cells
22. Inhibition of myogenic tone by mibefradil in rat cerebral arteries
23. - current in rabbit coronary artery myocytes
24. - channel. Development of inhibitory ligands
25. Molecular biology of α-adrenergic receptors: Implications for receptor classification and for structure-function relationships
26. 2+ influx in rat caudal artery
27. 2+ channels by RO 40-5967
28. - channel blockers inhibit myogenic tone in rat cerebral arteries
29. 2+ levels in vascular smooth muscle
30. - current in rat vascular smooth muscle cells in short-term primary culture
31. 2+ current is cultured single cells of rat portal vein
32. Pharmacological characterization of cloned alpha 1-adrenoceptor subtypes: Selective antagonists suggest the existence of a fourth subtype
33. 2+ channels in cardiac muscle and vascular smooth muscle
34. - channel inhibitor, indanyloxyacetic acid
35. 2+antagonists on resistance arteries of different end organs
36. Functional integrity of the central and sympathetic nervous system is a prerequisite for pressor and tachycardic effects of diphenyleneiodonium, a novel inhibitor of nitric oxide synthase