Morphine in cancer pain: Modes of administration

British Medical Journal

Volumn 312, Issue 7034, 1996, Pages 823-826

  Hanks, G W ^a   De Conno, F ^b   Ripamonti, C ^b   Ventafridda, V ^b   Hanna, M ^c   McQuay, H J ^d   Mercadante, S ^e   Meynadier, J ^f   Poulain, P ^g   Roca I Casas, J ^h  

^a BRISTOL HAEMATOLOGY AND ONCOLOGY CENTRE   (United Kingdom)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e Societa per L'Assistenza al M   (Italy)

^f CENTRE OSCAR LAMBRET   (France)

^g INSTITUT GUSTAVE ROUSSY   (France)

^h HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CODEINE; DIAMORPHINE; HYDROMORPHONE; MORPHINE; PARACETAMOL;

ANALGESIA; CANCER PAIN; CONFUSION; CONSTIPATION; DROWSINESS; DRUG BLOOD LEVEL; DRUG DEPENDENCE; DRUG FORMULATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; FEAR; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NAUSEA; ORAL DRUG ADMINISTRATION; PATIENT CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION; SHORT SURVEY; SUBCUTANEOUS DRUG ADMINISTRATION; SUBLINGUAL DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION; VOMITING;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, RECTAL; DELAYED-ACTION PREPARATIONS; HUMANS; INFUSIONS, INTRAVENOUS; MORPHINE; NEOPLASMS; PAIN; PALLIATIVE CARE;

EID: 9044253704     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (39)

1. World Health Organisation. Cancer pain relief. Geneva: WHO, 1986.
2. Ventafridda V, Tamburini M, Caraceni A, De Conno F, Naldi F. A validation study of the WHO method for cancer pain relief. Cancer 1987;59: 851-6.
3. Zech DFJ, Grond S, Lynch J, Hertel D, Lehmann KA. Validation of World Health Organisation guidelines for cancer pain relief. A 10-year prospective study. Pain 1995;63:65-76.
4. Schug SA, Zech D, Grond S, Jung H, Meuser T, Stobbe B. A long term survey of morphine in cancer pain patients. Journal of Pain and Symptom Management 1992;7:259-66.
5. Portenoy RK. Adjuvant analgesics in pain management. In: Doyle D, Hanks GWC, MacDonald N, eds. Oxford textbook of pallative medicine. Oxford: Oxford University Press, 1993:187-203.
6. Lasagna L. Addicting drugs and medical practice: towards the elaboration of realistic goals and the eradication of myths, mirages and half-truths. In: Wilner DM, Kassebaum GG, eds. Narcotics. New York: McGraw, 1965: 53-66.
7. Twycross RG. Pain relief in advanced cancer. Edinburgh: Churchill Livingstone, 1994:255-76.
8. Vainio A, Ollila J, Matikainen E, Rosenberg P, Kalso E. Driving ability in cancer patient? receiving long-term morphine analgesia. Lancet 1995;346: 667-70.
9. Hanks GW. Antiemetics for terminal cancer patients. Lancet 1982;ii:1410.
10. Foley KM. Current controversies in opioid therapy. In: Foley KM, Inturrisi CE, eds. Advances in pain research and therapy. Vol 8. Opioid analgesics in the management of cancer pain. New York: Raven Press, 1986:3-11.
11. Twycrcss RG. Opioid analgesics in cancer pain: current practice and controversies. Cancer Surg 1988;7:29-53.
12. Portenoy RK, Coyle N. Controversies in the long-term management of analgesic therapy in patients with advanced cancer. Journal of Pain and Symptom Management 1990;5:307-19.
13. McQuay HJ. The logic of alternative routes. Journal of Pain and Symptom Management 1990;5:75-7.
14. Sawe J. High dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment. Clin Pharmacokinet 1986;11:87-106.
15. Sawe J, Dahlstrom B, Rane A. Steady-state kinetics and analgesic effect of oral morphine in cancer patients. Eur J Clin Pharmacol 1983;24:537-42.
16. Poulain P, Hoskin PJ, Hanks GW, A-Omar O, Walker VA, Johnston A, et al. Relative bioavailability of controlled release morphine tablets (MST Continus) in cancer patients. Br J Anaesth 1988;61:569-74.
17. Hanks GW. Controlled-release morphine (MST-Contin) in advanced cancer. The European experience. Cancer 1989;63(suppl 1):2378-82.
18. Twycross RG. Control of pain. J R Coll Physicians Lond 1984;18:32-9.
19. Regnerd CFB, Badger C. Opioids, sleep and the time of death. Pathol Med 1987;1:107-10.
20. Leslie ST, Rhodes A, Black FM. Controlled release morphine sulphate tablets a study in normal volunteers. Br J Clin Pharmacol 1980;9:531-4.
21. Finn JW, Walsh TD, MacDonald N, Bruera E, Krebs LV, Shephard KV. Placebo-blinded study of morphine sulfate sustained-release tablets and immediate-release morphine sulfate solution in outpatients with chronic pain due to advanced cancer. J Clin Oncol 1993;11:967-72.
22. De Conno F, Ripamonti C, Saita L, MacEacher T, Hanson J, Bruera E. Role of rectal route in treating cancer pain: a randomized crossover clinical trial of oral versus rectal morphine administration in opioid-naive cancer patients with pain. J Clin Oncol 1995;13:1004-8.
23. Kaiko RF, Healy X, Pav J, Thomas GB, Goldenheim PD. The comparative bioavailability of MS Contin tablets (controlled release oral morphine) following rectal and oral administration. Royal Society of Medicine International Congress and Symposium Series 1989;149:235-41.
24. Hanks GW, Hoskin PJ, Aherne GW, Turner P, Poulain P. Explanation for potency of oral morphine on repeated dosage? Lancet 1987;ii:723-5.
25. McQuay HJ, Moore RA, Hand CW, Sear JW. Potency of oral morphine. Lancet 1987;ii:1458-9.
26. Kaiko RF. The therapeutic equivalence of IM and PO administration of morphine - 1:3 or 1:6. J Pathol Care 1988;4:64-6.
27. Twycross RG. The therapeutic equivalence of oral and subcutaneous/ intramuscular morphine sulphate in cancer patients. J Pathol Care 1988;4: 67-8.
28. Twycross RG, Lack SA, eds. Symptom control in far advanced cancer: pain relief. London: Pitman, 1983:190-9.
29. Dover SB. Syringe driver in terminal care. BMJ 1987;294:553-5.
30. Kalso E, Vainio A. Morphine and oxycodone hydrochloride in the management of cancer pain. Clin Pharmacol Ther 1990;47:639-46.
31. Hogan Q, Haddox JD, Abram S, Weissman D, Taylor ML, Janjan N. Epidural opiates and local anaesthetics for the management of cancer pain. Pain 1991;46:271-9.
32. Plummer JL, Cherry DA, Cousins MJ, Gourlay GK, Onley MM, Evans HKA. Longterm spinal administration of morphine in cancer and non-cancer pain: a restrospective study. Pain 1991;44:215-20.
33. Sjoberg M, Applegren L, Einarsson S, Hultman E, Linder LE, Nitescu P, Curelaru C. Longterm intrathecal morphine and bupivacaine in "refractory" cancer pain. I: Results from the first series of 52 patients. Acta Anaesthesiol Scand 1991;35:30-43.
34. Swarm RA, Cousins MJ. Anaesthetic techniques for pain control In: Doyle D, Hanks GWC, MacDonald N, eds. Oxford textbook of pullative medicine. Oxford: Oxford University Press, 1993:204-21.
35. Ripamonti C, Bruera E. Rectal, buccal, and sublingual narcotics for the management of cancer pain. J Pathol Care 1991;7:30-5.
36. Chrubasik J, Wust H, Friedrich G, Geller E. Absorption and bioavailability of nebulized morphine. Br J Anaesth 1988;61:228-30.
37. Inturrisi CE, Hanks GW. Opioid analgesic therapy. In: Doyle D, Hanks GWC, MacDonald N, eds. Oxford textbook of palliative medicine. Oxford, Oxford University Press, 1993:166-82.
38. Portenoy RK, Southam MA, Gupta SK, Lapjn J, Layman H, Inturrisi CE, et al. Transdermal fentanyl for cancer pain: repeated dose pharmacokinetics. Anesthesiology 1993;78:36-43.
39. Zech DFJ, Grond SUA, Lynch J, Dauer HG, Stollenwerk B, Lehmann KA. Transdermal fentanyl and initial dose-finding with patient-controlled analgesia in cancer pain. A pilot study with 20 terminally-ill cancer patients. Pain 1992;50:293-301.