Endotoxin augments cerebral hyperemic response to halothane by inducing nitric oxide synthase and cyclooxygenase

Anesthesia and Analgesia

Volumn 91, Issue 4, 2000, Pages 896-903

  Okamoto, Hirotsugu ^a   Roman, Richard J ^a   Kampine, John P ^a   Hudetz, Anthony G ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; ARGININE; BACTERIUM LIPOPOLYSACCHARIDE; CITRULLINE; CYCLOOXYGENASE 2; DEXAMETHASONE; DIETHYLAMINE; HALOTHANE; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD PH; BRAIN BLOOD FLOW; BRAIN CORTEX; CONTROLLED STUDY; DRUG SPECIFICITY; ENZYME ACTIVITY; ENZYME INDUCTION; HYPEREMIA; INHALATION ANESTHESIA; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASODILATATION;

EID: 0033795159     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200010000-00023     Document Type: Article

References (37)

1. Regional blood flow during isoflurane and halothane anesthesia
2. The effects of halothane and isoflurane on cerebrocortical microcirculation and autoregulation as assessed by laser-Doppler flowmetry
3. A comparison of the direct cerebral vasodilating potencies of halothane and isoflurane in the New Zealand white rabbit
4. Effect of halothane on large-conductance calcium-dependent potassium channels in cerebrovascular smooth muscle cells of the rat
5. Halothane vasodilation and nitric oxide in rat pial vessels
6. Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs
7. Isoflurane-induced cerebral hyperemia in neuronal nitric oxide synthase gene deficient mice
8. Neuronal NOS-derived NO plays permissive role in cerebral blood flow response to hypercapnia
9. Calcium-dependent and ATP-sensitive potassium channels and the 'permissive' function of cyclic GMP in hypercapnia-induced pial arteriolar relaxation
10. Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine
11. Cyclic nucleotide crosstalk and the regulation of cerebral vasodilation
12. Nitric oxide: Pathophysiological mechanisms
13. Role of inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-induced cerebral hyperemia
14. Mechanisms of endotoxin-induced dilatation of cerebral arterioles
15. Expression and vascular effects of cyclooxygenase in brain
16. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
17. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
18. Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat
19. Escherichia coli 0111 B4 lipopolysaccharide given intracisternally induces blood-brain barrier opening during experimental neonatal meningitis in piglets
20. Determination of anesthetic requirement in rats
21. Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation
22. Inducible nitric oxide synthase gene expression in brain following cerebral ischemia
23. Differential regulation of cyclo-oxygenase-1 and cyclo-oxygenase-2 gene expression by lipopolysaccharide treatment in vivo in the rat
24. Quantification of mRNA by non-radioactive RT-PCR and CCD imaging system
25. Assay of neuronal nitric oxide synthase by HPLC determination of citrulline
26. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: An alternative to radioimmunoassay
27. Cyclooxygenase-2 contributes to functional hyperemia in Whisker-Barrel cortex
28. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage
29. Effect of halothane on phenylephrine-induced vascular smooth muscle contractions in endotoxin-exposed rat aortic rings
30. 7-Nirtroindazole inhibits pial arteriolar vasodilation in a rat model of pneumococcal meningitis
31. Inhalational anesthetics up-regulate constitutive and lipopolysaccharide-induced inducible nitric oxide synthase expression and activity
32. Cerebellar nitric oxide is increased during isoflurane anesthesia compared to halothane anesthesia: A microdialysis study in rats
33. Permissive role of alpha-2 adrenoceptor-mediated dilations in rat cerebral arteries
34. Miconazole repress CO2-induced pial arteriolar dilation only under selected circumstances
35. Cyclic GMP causes Ca2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase
36. Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3':5'-monophosphate-dependent protein kinase
37. Effects of halothane and isoflurane on cytosolic calcium ion concentrations and contraction in the vascular smooth muscle of the rat aorta