Effect of viscous additives on drug absorption from the liver surface in rats using phenol red as a model

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 50, Issue 3, 2000, Pages 397-402

  Nishida, Koyo ^a   Nakakoga, Yuki ^a   Sato, Norihito ^a   Kawakami, Shigeru ^a   Mukai, Takahiro ^a   Sasaki, Hitoshi ^a   Sakaeda, Toshiyuki ^b   Nakamura, Junzo ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Absorption; Liver surface; Pharmacokinetic analysis; Phenol red; Viscous additive

Indexed keywords

CARBOXYMETHYLCELLULOSE; PHENOLSULFONPHTHALEIN; POLYVINYL ALCOHOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG URINE LEVEL; LIVER; MALE; NONHUMAN; RAT; SUSTAINED RELEASE FORMULATION; VISCOSITY;

ABSORPTION; ANIMAL; BILE; BODY FLUID COMPARTMENTS; BUFFERS; CARBOXYMETHYLCELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; EXCIPIENTS; INDICATORS AND REAGENTS; LIVER; MALE; MEMBRANES, ARTIFICIAL; MODELS, BIOLOGICAL; PERMEABILITY; PHENOLSULFONPHTHALEIN; POLYVINYL ALCOHOL; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; VISCOSITY;

EID: 0033791217     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(00)00112-0     Document Type: Article

References (24)

1. Absorption of organic anions as model drugs following application to rat liver surface in-vivo
2. Absorption characteristics of dextrans with different molecular weights from the liver surface membrane in rats: implications for targeting to the liver
3. Effect of albumin on the absorption of phenol red, bromphenol blue and bromosulphonphthalein as model drugs from the liver surface membrane in rats
4. Effect of application volume and area on the absorption of phenol red, as a model drug, from the liver surface in rats
5. Ocular evaluation of methylcellulose vehicle in albino rabbits
6. Ocular evaluation of polyvinyl alcohol vehicle in rabbits
7. Vehicle effects on ophthalmic bioavailability: the influence of different polymers on the activity of pilocarpine in rabbit and man
8. Sustained-release methotrexate for intracavitary chemotherapy
9. Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against sarcoma-180 bearing mice
10. Mechanism for drug absorption from rat-liver surface membrane: effect of dose and transport inhibitors on the pharmacokinetics of phenol red
11. The chemical forms in which phenol red is secreted into the bile of rats
12. Statistical moments in pharmacokinetics
13. A pharmacokinetic analysis program (MULTI) for microcomputer
14. Peritoneal membrane morphology and function
15. Pharmacokinetic and pharmacodynamic optimization of intraperitoneal chemotherapy
16. Pharmacokinetic problems in peritoneal drug administration: tissue penetration and surface exposure
17. Absorption of phenol red and bromphenol blue as model drugs from the peritoneal cavity around the liver surface in rats
18. Stealth liposomes: an improved sustained release system for 1-beta-D-arabinofuranosylcytosine
19. Paclitaxel-liposomes for intracavitary therapy of intraperitoneal P388 leukemia
20. effects of intraperitoneal administration of free and liposome-entrapped doxorubicin on rat peritoneal exudate cell populations
21. Adriamycin-loaded albumin-heparin conjugate microspheres for intraperitoneal chemotherapy
22. Pharmacological effects of 5-fluorouracil microspheres on peritoneal carcinomatosis in animals
23. Intraoperative chemotherapy with carbon particles adsorbing mitomycin C for gastric cancer with peritoneal dissemination in rabbits
24. Prophylaxis with carbon-adsorbed mitomycin against peritoneal recurrence of gastric cancer