Pharmacological effects of 5-fluorouracil microspheres on peritoneal carcinomatosis in animals

British Journal of Cancer

Volumn 74, Issue 9, 1996, Pages 1392-1396

  Hagiwara, A ^a   Takahashi, T ^a   Sawai, K ^a   Sakakura, C ^a   Tsujimoto, H ^a   Imanishi, T ^a   Ohgaki, M ^a   Yamazaki, J ^a   Muranishi, S ^b   Yamamoto, A ^b   Fujita, T ^b  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

5 Fluorouracil; Animal experiment; Intraperitoneal chemotherapy; Microsphere; Peritoneal carcinomatosis

Indexed keywords

FLUOROURACIL; MICROSPHERE; POLYGLACTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER TRANSPLANTATION; CARCINOMATOUS PERITONITIS; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MELANOMA CELL; MESENTERY; MOUSE; NONHUMAN; OMENTUM; PHARMACEUTICS; PRIORITY JOURNAL; RAT;

EID: 10344252272     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.554     Document Type: Article

References (16)

1. GYVES JW, ENSMINGER WD, STETSON P, NIEDERHUBER JE, MEYER M, WALKER S, JANIS MA AND GILBERTSON S. (1984). Constant intraperitoneal 5-fluorouracil infusion through a totally implanted system. Clin. Pharmacol. Therap., 34, 83 - 89.
2. HAGIWARA A, TAKAHASHI T, UEDA T, LEE R, TAKEDA M AND ITOH T. (1988). Intraoperative chemotherapy with carbon particles adsorbing mitomycin C for gastric cancer with peritoneal dissemination in rabbits. Surgery, 104, 874 - 881.
3. HAGIWARA A, TAKAHASHI T, KOJIMA O, SAWAI K, YAMAGUCHI T, YAMANE T, TANIGUCHI H, KITAMURA K, NOGUCHI A, SEIKI K AND SAKAKURA C. (1992). Prophylaxis with carbon-adsorbed mitomycin against peritoneal recurrence of gastric cancer. Lancet, 339, 629 - 631.
4. HAGIWARA A, TAKAHASHI T, SAWAI K, TANIGUCHI H, SHIMOTSUMA M, OKANO S, SAKAKURA C, TSUJIMOTO H, OSAKI K, SASAKI S AND SHIRASU M. (1993a). Milky spots as the implantation site for malignant cells in peritoneal dissemination in mice. Cancer Res., 53, 687 - 692.
5. HAGIWARA A, TAKAHASHI T, KOJIMA O, YAMAGUCHI T, SASABE T, LEE M, SAKAKURA C, SHOUBAYASHI S, IKADA Y AND HYON SH. (1993b). Pharmacologic effects of cisplatin microspheres on peritoneal carcinomatosis in rodents. Cancer, 71, 844 - 850.
6. HAGIWARA A, TAKAHASHI T, SAKAKURA C, SHIRASU M, TSUJIMOTO H, OHGAKI M AND YAMAZAKI J. (1996). Targeting chemotherapy for peritoneally implanted malignant cells using microspheres: a morphological study in mice (in Japanese). Igakunoayumi (submitted).
7. INABA M, MITSUBAYASHI J AND OZAWA S. (1990). Kinetic analysis of 5-fluorouracil action against various cancer cells. Jpn. J. Cancer Res., 81, 1039 - 1044.
8. JONES RA, BUCKPITT AR, LONDER HH, MEYERS CE, CHABNER BA AND BOYD MR. (1979). Potential clinial applications of a new method for quantitation of plasma levels of 5-fluorouracil and 5-fluorodeoxyuridine. Bull. Cancer, 66, 75 - 78.
9. JONES RB, MYERS CE, GUARINO AM, DEDRICK RL, HUBBARD SM AND DEVITA VT. (1978). High volume intraperitoneal chemotherapy ('belly bath') for ovarian cancer. Cancer Chemother. Pharmacol., 1, 161 - 166.
10. MASUIKE T, WATANABE I AND TAKEMOTO Y. (1985). Quantitative method of 5-fluorouracil and its metabolites in biological samples using high performance liquid chromatography. Yakugakuzasshi, 105, 1058 - 1064 (in Japanese with English summary).
11. MANDACHE E, NEGOESCU A AND MOLDOVEANU E. (1989). The development of lymphatic follicules in the omentum after intraperitoneal stimulation of rats. Morphol. Embryol., 35, 139 - 147.
12. OGAWA Y, OKADA H, YAMAMOTO M AND SIMAMOTO T. (1988). In vivo release profiles of leuprolide acetate from microspheres prepared with polyacetic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers. Chem. Pharm. Bull., 36, 2576 - 2581.
13. RUSZNYAK I, FOLDI M AND SZABO G. (1967). Filtration and absorption through serous membranes. In Lymphatics and Lymph Circulation - Physiology and Pathology. 2nd ed. Youlten L. (ed.) pp. 475 - 510. Pergamon Press: London.
14. SPEYER JL, COLLINS JM, DEDRICK RL, BRENNAN MF, BUCKPITT AR, LONDER H, DEVITA VT Jr AND MYERS CF. (1980). Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally. Cancer Res., 40, 567 - 572.
15. SUGARBAKER PH, GIANOLA FJ, SPEYER JC, WELSEY R, BAROFSKY I AND MEYERS CE. (1985). Prospective, randomized trial of intravenous versus intraperitoneal 5-fluorouracil in patients with advanced primary colon or rectal cancer. Surgery, 98, 414 - 422.
16. TSUJIMOTO H, TAKAHASHI T, HAGIWARA A, SAKAKURA C, OSAKI K, SASAKI S, SHIRASU M, SAKAKIBARA T, OHYAMA T, SAKUYAMA A, OHGAKI M, IMANISHI T AND YAMAZAKI J. (1995). Site-specific implantation in the milky spots of malignant cells in peritoneal dissemination: immunohistochemical observation in mice inoculated intraperitoneally with bromodeoxyuridine-labelled cells. Br. J. Cancer, 71, 468 - 472.