Prevalence and clinical significance of HFE gene mutations in patients with iron overload

American Journal of Gastroenterology

Volumn 95, Issue 10, 2000, Pages 2910-2914

  Brandhagen, D J ^a   Fairbanks, V F ^a   Baldus, W P ^a   Smith, C I ^b   Kruckeberg, K E ^a   Schaid, D J ^a   Thibodeau, S N ^a  

^a MAYO CLINIC   (United States)

^b Minnesota Gastroenterology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME ANALYSIS; DATA ANALYSIS; GENE EXPRESSION; GENE MUTATION; HEMOCHROMATOSIS; HUMAN; IRON OVERLOAD; MAJOR CLINICAL STUDY; PHLEBOTOMY; PREVALENCE; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RISK FACTOR; SPECTROPHOTOMETRY;

AGED; ALLELES; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMAN; MALE; MIDDLE AGE;

EID: 0033787993     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(00)01996-1     Document Type: Article

References (22)

1. Association of HLA-A3, and HLA-B14 antigens with idiopathic hemochromatosis
2. A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis
3. β2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocomopatibility complex in iron metabolism
4. Iron overload in β2-microglobulin-deficient mice
5. Mutation analysis in hereditary hemochromatosis
6. Mutations in the MHC class I-like candidate gene for hemochromatosis in French patients
7. Correlation between genotype and phenotype in hereditary hemochromatosis: Analysis of 61 cases
8. Mutation analysis of the HLA-H gene in Italian hemochromatosis patients
9. A simple genetic test identifies 90% of UK patients with haemochromatosis
10. Genetic and clinical description of hemochromatosis probands and heterozygotes: Evidence that multiple genes linked to the major histocompatibility complex are responsible for hemochromatosis
11. Diagnosis of hemochromatosis gene mutations: The H63D mutation must be tested
12. Analysis of HFE-codon 63/282 (H63D/282Y) gene variants in German hemochromatosis patients
13. Routine analysis of copper and iron in liver by inductively coupled plasma emission spectroscopy
14. The estimation and significance of the logarithm of a ratio of frequencies
15. Polymorphism in intron 4 of HFE may cause overestimation of C282Y homozygote prevalence in hemochromatosis
16. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
17. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
18. Hemochromatosis mutations C282Y and H63D in 'cis' phase
19. The significance of the 187G (H63D) mutation in hemochromatosis
20. Hemochromatosis, HFE, and genetic complexity