Oxidative inactivation of brain ecto-5'-nucleotidase by thiols/Fe2+ system

Neurochemical Research

Volumn 25, Issue 11, 2000, Pages 1475-1484

  Liu, Xi Wen ^a   Sok, Dai Eun ^a  

^a Chungnam National University   (South Korea)

Author keywords

5' Nucleotidase; Ferrous ions; Oxidant radicals; Selective inactivation; Thiols

Indexed keywords

ADENOSINE PHOSPHATE; ALCOHOL; ASCORBIC ACID; BENZOIC ACID; CATALASE; COPPER ION; ECTO 5' NUCLEOTIDASE; FERROUS ION; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MANGANESE; MANNITOL; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE; ZINC ION;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CATTLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL;

5'-NUCLEOTIDASE; ANIMALS; BRAIN; CATTLE; FERROUS COMPOUNDS; OXIDANTS; OXIDATION-REDUCTION; SULFHYDRYL COMPOUNDS;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0033787876     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007624125136     Document Type: Article

References (40)

1. 5'-Nucleotidase, molecular structure and funtional aspects
2. 5'-Nucleotidases in rat heart. Evidence for the occurrence of two soluble enzymes with different substrate specificities
3. IMP-GMP 5'-Nucleotidase from rat brain: Activation by polyphosphates
4. Function of 5'-nucleotidase in the uptake of adenosine from AMP by human lymphocytes
5. Metabolism of adenosine nucleotides by ectoenzymes of vascular endothelial and smooth-mucscle cells in culture
6. Adenosine receptor subtypes
7. Adenosine, antioxidant enzymes and cytoprotection
8. Excess brain protein oxidation and enzyme dysfuntion in normal aging and in Alzheimer's disease
9. Oxidants, antioxidants, and degenerative diseases of aging
10. Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis
11. Oxidative stress, antioxidants, aging and disease
12. Evidence for neuronal oxidation damage in Alzheimer's disease
13. Oxidative damage to proteins and lipids of brain myelin produced by in vivo generated reactive oxygen species
14. Activation of adenylate cyclase of rat brain by lipid peroxidation
15. Reduced phosphorylcholine hydrolysis by homogenates of temporal regions of Alzheimer's brain
16. +-ATPase, 5'-nucleotidase and CNPase in mouse brain myelin
17. Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclrerosis plaques
18. Reduced phospholipase D activity in brain tissue samples from Alzheimer's disease patients
19. 2+-glycerophosphocholine cholinephosphodiesterase
20. Oxidative inactivation of brain alkaline phosphatase responsible for hydrolysis of phosphocholine
21. Lipid peroxidation as the mechanism of modification of brain 5'-nucleotidase activity in vitro
22. Lipid peroxidation causes an increase of lipid order and a decrease of 5'-nucleotidase activity in the liver plasma membrane
23. Inhibition of ecto-5'-nucleotidase by nitric oxide donors
24. Nucleotide phosphomonoesterases
25. 2+-requiring glycerophosphocholine cholinephosphodiesterase possessing p-nitrophenylphosphocholine phosphodiesterase activity
26. A low -Km 5'-nucleotidase from rat brain cytosolic fraction: Purification, kinetic properties, and descriptipon of regulation by a novel factor that increases sensitivity to inhibition by ATP and ADP
27. Effects of dithiothreitol, dithioerythritol and chelating agents on 5'-nucleotidase from bull seminal plasma
28. Equilibria and thermodynamics in biochemical transformations
29. Cellular functions of metallo-endoproteinases
30. 2+-isocitrate
31. The generation of hydrogen peroxide, superoxide radical, and hydroxy radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
32. Subcellular localization of 5'-nucleotidase in rat brain
33. Turnover of bacterial glutamine synthetase: Oxidative inactivation precedes proteolysis
34. Metal-catalyzed oxidation of proteins
35. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
36. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
37. Regional Distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease
38. Roles of adenosine and theophylline on the recovery of adenine nucleotides in postischemic cultured renal tubular cells
39. Regulation of cardiac AMP-specific 5'-nucleotidase during ischemia mediates ATP resynthesis on reflow