The lysosomal protease cathepsin D is efficiently sorted to and secreted from regulated secretory compartments in the rat basophilic/mast cell line RBL

Journal of Cell Science

Volumn 113, Issue 18, 2000, Pages 3289-3298

  Dragonetti, A ^a   Baldassarre, M ^a   Castino, R ^a   Demoz, M ^a   Luini, A ^a   Buccione, R ^a   Isidoro, C ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Lysosomal protease; Mast cell; Secretory lysosome

Indexed keywords

2,4 DINITROPHENOL; AMMONIUM CHLORIDE; BIOLOGICAL MARKER; BOVINE SERUM ALBUMIN; CALCIUM; CATHEPSIN D; EGTAZIC ACID; HYDROLASE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; PROTEINASE; TOLONIUM CHLORIDE;

ANIMAL CELL; ARTICLE; BASOPHIL; BIOGENESIS; CALCIUM TRANSPORT; CELL ACTIVITY; CELL COMPARTMENTALIZATION; CELL GRANULE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENZYME LOCALIZATION; ENZYME REGULATION; ENZYME RELEASE; EXOCYTOSIS; IMMUNOSTIMULATION; INFLAMMATION; LYSOSOME; MAST CELL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN TARGETING; RAT; SECRETORY CELL;

ANIMAL; ANTIGENS; BASOPHILS; CALCIUM; CATHEPSIN D; DINITROPHENOLS; ENDOCYTOSIS; ENDOSOMES; EXOCYTOSIS; LYSOSOMES; MANNOSEPHOSPHATES; MAST CELLS; RATS; SERUM ALBUMIN, BOVINE; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0033785510     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
2. Sorting and storage during secretory granule biogenesis: Looking backward and looking forward
3. Regulation of protein sorting at the TGN by plasma membrane receptor activation
4. Study of the transit of an integral membrane protein from secretory granules through the plasma membrane of secreting rat basophilic leukemia cells using a specific monoclonal antibody
5. In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells
6. Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments
7. Analysis of protein kinase C requirement for exocytosis in permeabilised rat basophilic leukemia RBL-2H3 cells: A GTP-binding protein(s) as a potential target for protein kinase C
8. The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments
9. Regulation of rat hepatocyte protein kinase C β isoenzyme by the lipid peroxidation product 4-hydroxy-2, 3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins
10. Transformation by oncogenic Ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D
11. Histamine distribution in human basophil secretory granules undergoing FMLP-stimulated secretion and recovery
12. Circular ruffle formation in rat basophilic leukemia cells in response to antigen stimulation
13. Rat peritoneal mast cells present antigene to a PPD-specific T cell line
14. Exogenous and endogenous antigen are differentially presented by mast cells to CD4+T lymphocytes
15. Isolation and sequencing of a cDNA clone encoding rat liver lysosomal cathepsin D and the structure of three forms of mature enzymes
16. Mast cell cytokines in allergy and inflammation
17. Mannose 6-phosphate-independent targeting of lysosomal enzymes in cell disease B lymphoblasts
18. The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts
19. Mast cells as a source of multifunctional cytokines
20. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor
21. Secretory lysosomes - A special mechanism of regulated secretion in haemopoietic cells
22. Cathepsin D-mediated processing of procollagen: Lysosomal enzyme involvement in secretory processing of procollagen
23. The early and late processing of lysosomal enzymes: Proteolysis and compartmentation
24. Cathepsin D targeted by acid sphingomyelidae-derived ceramide
25. Stimulation of DNA synthesis by cathepsin D digest of fibronectin
26. 4Cl
27. High levels of proteolytic enzymes in the ascitic fluid and plasma of rats bearing the Yoshida AH-130 hepatoma
28. Exposed thiols confer localization in the endoplasmic reticulum by retention rather than retrieval
29. Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI
30. Differential sorting of lysosomal enzymes of the regulated secretory pathway in pancreatic β-cells
31. Protein measurement with folin phenol reagent
32. Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells
33. Translocation and clustering of endosomes and lysosomes depends on microtubules
34. Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts
35. Lymphokine and cytokine production by Fce RI+ cells
36. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
37. Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation
38. 2+-regulated exocytic vesicles in fibroblasts and epithelial cells
39. Cathepsin B-mediated activation of the proinflammatory caspase-11
40. Enzymes of the mast cell granule
41. The fibrin(ogen)olytic properties of cathepsin D
42. Regulated secretion of hemopoietic cells
43. Lysosomal enzymes and their receptors
44. Structures at the proteolytic processing region of cathepsin D