Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP- specific phosphodiesterase and of malignant tumor cell growth

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4733-4743

  Merz, Karl Heinz ^a   Marko, Doris ^a   Regiert, Thomas ^a   Reiss, Guido ^a   Frank, Walter ^a   Eisenbrand, Gerhard ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

7 BENZYLAMINO 6 CHLORO 2 PIPERAZINO 4 PYRROLIDINOPTERIDINE; PHOSPHODIESTERASE INHIBITOR; PTERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; GROWTH REGULATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY; XENOGRAFT;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; ISOENZYMES; LUNG NEOPLASMS; MICE; MICE, NUDE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PTERIDINES; RHODAMINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0032548076     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981021v     Document Type: Article

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