The mitochondrial protein import motor

Biological Chemistry

Volumn 381, Issue 9-10, 2000, Pages 943-949

  Strub, A ^a   Lim, J H ^a   Pfanner, N ^a   Voos, W ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Heat shock protein; Mge1; Mitochondria; MtHsp70; Protein import; Tim44

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; HEAT SHOCK PROTEIN 70; MUTANT PROTEIN; OUTER MEMBRANE PROTEIN; POLYPEPTIDE; PROTEIN PRECURSOR;

CARBOXY TERMINAL SEQUENCE; CELL ORGANELLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; HYDROLYSIS; MEMBRANE POTENTIAL; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOLECULAR INTERACTION; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW;

EID: 0033782977     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2000.115     Document Type: Review

References (33)

1. Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane
2. Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins
3. The Hsp70 and Hsp60 chaperone machines
4. Strong precursorpore interactions constrain models for mitochondrial protein import
5. Role of mitochondrial GrpE and phosphate in the ATPase cycle of matrix Hsp70
6. The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44
7. A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins
8. Unfolding of preproteins upon import into mitochondria
9. Can Hsp70 proteins act as force-generating motors?
10. Molecular chaperones in cellular protein folding
11. Post-translational protein import and folding
12. What is the driving force for protein import into mitochondria?
13. Mitochondria unfold precursor proteins by unraveling them from their N-termini
14. Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins
15. BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane
16. The J-related segment of Tim44 is essential for cell viability: A mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation
17. Mge1 functions as a nucleotide release factor for Ssc1, a mitochondrial Hsp70 of Saccharomyces cerevisiae
18. Protein import into mitochondria
19. Protein sorting: Pulling in the proteins
20. The preprotein translocase of the mitochondrial inner membrane: Function and evolution
21. Recognition and binding of mitochondrial presequences during the import of proteins into mitochondria
22. The preprotein translocase of the mitochondrial outer membrane
23. Common principles of protein translocation across membranes
24. Mitochondrial Hsp70/MIM44 complex facilitates protein import
25. What drives the translocation of proteins?
26. Import of carrier proteins into mitochondria
27. The role of hsp70 in conferring unidirectionality on protein translocation
28. The delta psi- and Hsp70/MIM44-dependent reaction cycle driving early steps of protein import into mitochondria
29. The protein import motor of mitochondria: Unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70
30. The mitochondrial protein import machinery. Role of ATP in dissociation of the Hsp70-Mim44 complex
31. Mitochondrial GrpE is present in a complex with hsp70 and preproteins in transit across membranes
32. Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins
33. Mechanisms of protein translocation into mitochondria