Phenylalanine dehydrogenase catalyzed reductive amination of 6-(1',3'-dioxolan-2'-yl)-2-keto-hexanoic acid to 6-(1',3'-dioxolan-2'-yl)-2S-aminohexanoic acid with NADH regeneration and enzyme and cofactor retention

Biocatalysis and Biotransformation

Volumn 18, Issue 5, 2000, Pages 373-400

  Stengelin, M ^a   Patel, R N ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

2S aminohexanoic acid; Formate dehydrogenase; Phenylalanine dehydrogenase

Indexed keywords

AMINATION; BIODEGRADATION; CATALYSIS; DIFFUSION; ENCAPSULATION; ENZYMES; LITHIUM COMPOUNDS; MEMBRANES; SALTS; STABILITY;

AMINOHEXANOIC ACID; BIOTRANSFORMATION; COFACTORS; FORMATE DEHYDROGENASE; LITHIUM SALT; PHENYLALANINE DEHYDROGENASE; SEMIPERMEABLE MICROCAPSULES;

ORGANIC ACIDS;

ENZYME; FORMATE DEHYDROGENASE; HEXANOIC ACID DERIVATIVE; LITHIUM SALT; MACROGOL 20000; MACROGOL DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; PHENYLALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

AMINATION; ARTICLE; BIOTECHNOLOGY; BIOTRANSFORMATION; CANDIDA BOIDINII; CATALYSIS; ENCAPSULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME IMMOBILIZATION; ENZYME STABILITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; FERMENTATION; MEMBRANE REACTOR; MICROCAPSULE; NONHUMAN; PICHIA PASTORIS; REACTION ANALYSIS;

CANDIDA BOIDINII; ESCHERICHIA COLI; PICHIA PASTORIS; TRIXIS;

EID: 0033782536     PISSN: 10242422     EISSN: None     Source Type: Journal    
DOI: 10.3109/10242420009015258     Document Type: Article

References (43)

1. A new synthesis of coenzymatically active water-soluble macromolecular NAD and NADP derivatives
2. A different acceptance of adenine-modified NADP by NADP-dependent glucose dehydrogenase from Bacillus megaterium and strictly NADP-dependent glucose dehydrogenase from Cryptococcus uniguttulatus
3. An efficient synthesis of high-molecular-weight NAD(H) derivatives suitable for continuous operation with coenzyme-dependent enzyme systems
4. 6-(2-Aminoethyl)-NADH by a procedure adaptable to large-scale synthesis
5. Semipermeable microcapsules
6. Stabilization of enzymes by microencapsulation with a concentrated protein solution or by microencapsulation followed by crosslinking with glutaraldehyde
7. Artificial cells in medicine and biotechnology
8. Artificial cells containing multienzyme systems
9. Recycling of NAD(P) by multienzyme systems immobilized by microencapsulation in artificial cells
10. Bioencapsulation in biotechnology
11. Semipermeable aqueous microcapsules (artificial cells). V. Permeability characteristics
12. Semipermeable aqueous microcapsules
13. Regeneration of nicotinamide cofactors for use in organic synthesis
14. Cofactor regeneration for enzyme catalyzed synthesis
15. Hydrodynamics and urea hydrolysis in a microencapsulated urease, fluidized bed reactor
16. Nylon polyethyleneimine microcapsules for immobilizing multienzyme systems with soluble dextran-NAD for the continuous recycling of the microencapsulated dextran-NAD
17. Conversion of α-ketoglutarate into L-glutamic acid with urea as ammonium source using multienzyme systems and dextran-NAD immobilized by microencapsulation within artificial cells in a bioreactor
18. Conversion of ammonia or urea into essential amino acids, L-leucine, L-valine and L-isoleucine, using artificial cells containing an immobilized multienzyme systems and dextran-NAD
19. Coenzymatic properties of macromolecular derivatives of NAD and NADP with two thermostable dehydrogenases from the archeobacterium Sulfolobus solfataricus
20. Synthesis of allylysine ethylene acetal using phenylalanine dehydrogenase from Thermoactinomyces intermedius
21. Continuous processes with soluble enzymes
22. Enzyme engineering aspects of biocatalysis: Cofactor regeneration as example
23. Scale-up of formate dehydrogenase by partition
24. Continuous enzymatic transformation in an enzyme membrane reactor with simultaneous NADH regeneration
25. The preparation and characterisation of a water-soluble coenzymatically active dextran-NAD
26. Blood urea clearance with microencapsulated urease
27. Nylon microcapsules. II. Effect of selected variables on theophylline release
28. Nylon-encapsulated pharmaceuticals
29. Permeability and molecular sieving characteristics of nylon microcapsule membrane
30. Interfacial polycondensation. II. Fundamentals of polymer formation at liquid interfaces
31. Microencapsulation of bovine liver arginase: Characterization and in vivo evaluation of its effect on the growth of the L1210 murine leukemia
32. Stereoselective biotransformations in synthesis of some pharmaceutical intermediates
33. Nylon membrane formation in biocatalyst microencapsulation: Physiochemical modeling
34. Dual metalloprotease inhibitors: Mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase
35. Stereospecific hydrogenations with immobilized microbial cells or enzymes
36. Continuous (R)-mandelic acid production in an enzyme membrane reactor
37. Recycling of NAD crosslinked to albumin or hemoglobin immobilized with multienzyme systems in artificial cells
38. Coenzyme regeneration in membrane reactors
39. Continuous computer controlled production of formate dehydrogenase (FDH) and isolation on a pilot scale
40. Continuous enzymatic transformation in an enzyme membrane reactor with simultaneous NAD(H) regeneration
41. A novel two-step procedure for immobilizing living cells in microcapsules for improving xenograft survival
42. Enzymes in synthetic organic chemistry