Oxygen-free radicals directly attack the ATP binding site of the cardiac Na+,K+-ATPase

Annals of the New York Academy of Sciences

Volumn 834, Issue , 1997, Pages 680-683

  Xu, K Y ^a   Zweier, Jay L ^a   Becker, Lewis C ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; HEART ENZYME; OXYGEN RADICAL; SUCROSE;

ANIMAL TISSUE; BINDING SITE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME DENATURATION; ENZYME INHIBITION; NONHUMAN; RAT; SIMULATION;

ANIMALIA;

EID: 0031440859     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb52349.x     Document Type: Conference Paper

References (7)

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2. +-ATPase. Am. J. Physiol. 252: H252-257.
3. ZWEIER, J. L. 1988. Measurement of superoxide-derived free radicals in reperfused heart. J. Biol. Chem. 263: 1353-1357.
4. JONES, L. R. 1988. Rapid preparation of canine cardiac sarcolemmal vesicles by sucrose flotation. Methods Enzymol. 157: 85-91.
5. +)-activated adenosine triphosphatase from rat. Anal. Biochem. 175: 284-288.
6. KYTE, J. 1971. Purification of the sodium- and potassium-dependent triphosphatase from canine renal medulla. J. Biol. Chem. 246: 4157-4165.
7. JOSEPHON, R. A., H. S. SILVERMAN, E. G. LAKATTA, M. D. STERN & J. L. ZWEIER. 1991. Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes. J. Biol. Chem. 266: 2354-2361.