28S ribosome degradation in lymphoid cell apoptosis: Evidence for caspase and Bcl-2-dependent and -independent pathways

Cell Death and Differentiation

Volumn 7, Issue 10, 2000, Pages 994-1001

  King, K L ^a,b   Jewell, C M ^a   Bortner, C D ^a   Cidlowski, J A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Apoptosis; Glucocorticoidis; Ribosomes; RNA degradation

Indexed keywords

CALCIMYCIN; CALCIUM IONOPHORE; CASPASE; CASPASE INHIBITOR; GLUCOCORTICOID; PROTEIN BCL 2; RNA 28S;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL VIABILITY; CELL VOLUME; CONTROLLED STUDY; DEGRADATION; DNA DEGRADATION; ENZYME ACTIVATION; EXPOSURE; LYMPHOCYTE; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; RNA DEGRADATION; SIGNAL TRANSDUCTION; THYMOMA;

EID: 0033778361     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400731     Document Type: Article

References (33)

1. Apoptosis: Mechanisms and roles in pathology
2. Apoptosis: The biochemistry and molecular biology of programmed cell death
3. Caspases: The executioners of apoptosis
4. ICE-like proteases in apoptosis
5. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
6. Yama/CPP32b, a mammalian homolog of CED-3, is a crm-A-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase
7. Caspases and caspase inhibitors
8. Caspase independent/dependent regulation of K+, cell shrinkage, and mitochondrial potential during lymphocyte apoptosis
9. The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system
10. Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid
11. Glucocorticoids stimulate ribonucleic acid degradation in isolated rat thymic lymphocytes in vitro
12. Glucocorticoids stimulate protein degradation in lymphocytes: A possible mechanism of steroid-induced cell death
13. Glucocorticoids inhibit precursor incorporation into protein in splenic lymphocytes by stimulating protein degradation and expanding intracellular amino acid pools
14. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
15. Bcl-2 inhibits glucocorticoid-induced apoptosis but only partially blocks calcium ionophore or cycloheximide-regulated apoptosis in S49 cells
16. Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis
17. Fine mapping of 28SrRNA sites specifically cleaved in cells undergoing apoptosis
18. X-Ray-induced transcription and apoptosis-associated loss of 28S rRNA in interphase human lymphocytes
19. The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation
20. Differentiated functions expressed by cultured mouse lymphoma cells: I. Specificity and kinetics of cell responses to corticosteroids
21. Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma
22. bcl-2gene transfer increases relative resistance of S49.1 and WEHI17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
23. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes
24. A primary role for K+ and Na+ efflux in the activation of apoptosis
25. Intracellular K+ suppresses the activation of apoptosis in lymphocytes
26. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
27. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
28. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide
29. Expression of members of the Bcl-2 gene family in the immature rat ovary: Equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and ribonucleic acid levels
30. Accumulation of sequence-specific RNA-binding proteins in the cytosol of activated T cells undergoing RNA degradation and apoptosis
31. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction