Relationship between expression of topoisomerase II isoforms and chemosensitivity in choroidal melanoma

Journal of Pathology

Volumn 192, Issue 2, 2000, Pages 174-181

  Satherley, Kirsten ^a   De Souza, Lavinia ^a   Neale, Michael H ^a   Alexander, Robert A ^a   Myatt, Nyree ^a   Foss, Alex J E ^b   Hungerford, John L ^c   Hickson, Ian D ^d   Cree, Ian A ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

^c MOORFIELDS EYE HOSPITAL   (United Kingdom)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Doxorubicin; Eye; Melanoma; Mitoxantrone; Topoisomerase II beta

Indexed keywords

ANTHRACYCLINE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ISOPROTEIN; MITOXANTRONE; VINCRISTINE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CHEMOSENSITIVITY; CHOROID MELANOMA; CHROMOSOME 3; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MONOSOMY; MULTIDRUG RESISTANCE; MULTIVARIATE ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UVEA MELANOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTIBIOTICS, ANTHRACYCLINE; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHOROID NEOPLASMS; DNA TOPOISOMERASES, TYPE I; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMAN; ISOENZYMES; MALE; MELANOMA; MIDDLE AGE; MITOXANTRONE; NEOPLASM PROTEINS; PREDICTIVE VALUE OF TESTS; VINCRISTINE;

EID: 0033776290     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH677>3.0.CO;2-H     Document Type: Article

References (37)

1. Prognostic parameters in uveal melanoma: A review
2. Thames Cancer Registry, Cancer in South East England 1992
3. Uveal melanoma in Finland. An epidemiological, clinical, histological and prognostic study
4. Treatment of uveal melanoma metastatic to the liver: A review of the M. D. Anderson Cancer Center experience and prognostic factors
5. The ex vivo chemosensitivity profile of choroidal melanoma
6. Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: Clinical correlation for cisplatin resistance of ovarian carcinoma
7. Heterogeneity of chemosensitivity in human breast carcinoma: Use of an adenosine triphosphate (ATP) chemiluminescence assay
8. Correlation of the clinical response to chemotherapy in breast cancer with ex vivo chemosensitivity
9. Chemotherapy directed by the ATP tumour chemosensitivity assay improves response rates and survival for patients with recurrent ovarian cancer
10. Combination chemotherapy for choroidal melanoma: Ex vivo sensitivity to treosulfan with gemcitabine or cytosine arabinoside
11. Prediction of response to drug therapy of cancer. A review of in vitro assays
12. In vitro drug sensitivity testing for the individual patient: An ideal adjunct to current methods of treatment choice
13. Individualizing chemotherapy for solid tumours-is there any alternative?
14. The role of topoisomerase II in multidrug resistance
15. Quantitation of the granuloma fraction in leprosy skin biopsies by planimetry
16. Histological assessment of osteoporosis by iliac crest biopsy
17. Ki-67 and bromodeoxyuridine labeling of human choroidal melanoma cells
18. The distribution and expression of the two isoforms of topoisomerase II in normal and neoplastic human tissues
19. Structure and function of type II DNA topoisomerases
20. DNA topisomerases
21. Genetic aspects of uveal melanoma. A brief review
22. Abnormalities of chromosome 3 and 8 in posterior uveal melanoma correlate with prognosis
23. Prognostic implications of monosomy 3 in uveal melanoma
24. A role for the transforming growth factor-beta pathway in choroidal melanoma
25. Acquisition of multiple copies of a mutant topoisomerase II alpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines
26. Doxorubicin-induced DNA breaks, topoisomerase II activity and gene expression in human melanoma cells
27. Mitoxantrone combined with paclitaxel as salvage therapy for platinum-refractory ovarian cancer: Laboratory study and clinical pilot trial
28. Heterogeneity of chemosensitivity of metastatic cutaneous melanoma
29. Multidrug resistance in ocular melanoma
30. Multidrug resistance-related proteins in primary choroidal melanomas and in vitro cell lines
31. Increased mdr gene expression and decreased drug accumulation in multidrug-resistant human melanoma cells
32. Cellular resistance to anthracyclines
33. The role of DNA mismatch repair in drug resistance
34. c-myc, p53 and bcl-2 expression and clinical outcome in uveal melanoma
35. Drug resistance in ovarian cancer-the role of p53
36. Expression of the p53 tumour suppressor gene product is a determinant of chemosensitivity