Inhibition of tumor necrosis factor- α mRNA expression by a limited series of tetrahydroisoquinolines in mouse peritoneal macrophages

Korean Journal of Physiology and Pharmacology

Volumn 4, Issue 4, 2000, Pages 325-331

  Tae Ho Jung, ^a   Young Soo Lee, ^a   Young Jin Kang, ^a   Bog Kyu Lee, ^a   Young Shin Ko, ^a   Han Geuk Seo, ^a   Soo Youn Chung, ^a   Lee, D H ^a   Hye Sook Yun Choi, ^a   Ki Churl Chang, ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Inducible nitric oxide synthase; Inflammation; Lipopolysaccharide; Nitric oxide; Tetrahydroisoquinolines; Tumor necrosis factor

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; GAMMA INTERFERON; HIGENAMINE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; TETRAHYDROISOQUINOLINE DERIVATIVE; THI 52; THIOGLYCOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; YS 51;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; FIBROBLAST; INFLAMMATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION;

EID: 0033771130     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Expression of tumor necrosis factor in human acute cardiac rejection. An immunohistochemical and immunoblotting study
2. Tetrandrine inhibits NF-kB activation in rat alveolar macrophages
3. Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages
4. Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors
5. Inhibition by higenamine of lipopolysaccharide-induced iNOS mRNA expression and NO production in rat aorta
6. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages
7. Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root
8. NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs
9. Suppression of lipopolysaccharide-induced fulminant hepatitis and tumor necrosis factor production by bisbenzylisoquinoline alkaloids in bacillus Calmette-Guerin-treated mice
10. Inhibitory effect of bisbenzylisoquinoline alkaloids on nitric oxide production in activated macrophages
11. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
12. Unraveling the biological significance of nitric oxide
13. Relaxation of distal colonic circular smooth muscle by nitric oxide derived from human leucocytes
14. New insights into the regulation of inducible nitric oxide synthesis
15. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy
16. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
17. Hepatocyte-derived interleukin-6 and tumor-necrosis factor alpha mediate the lipopolysaccharide-induced acute-phase response and nitric oxide release by cultured rat hepatocytes
18. Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis
19. Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo
20. Drugs which modulate nitric oxide homeostasis are likely to provide therapeutic benefit in cardiovascular disease
21. Shock and tissue injury induced by recombinant human cachectin
22. Terbutaline prevents circulatory failure and mitigates mortality in rodents with endotoxemia
23. A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase