In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): Metabolism of benzydamine and caffeine by FMO and P450 isoforms

British Journal of Clinical Pharmacology

Volumn 50, Issue 4, 2000, Pages 311-314

  Lang, Dieter H ^b   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BAYER AG   (Germany)

Author keywords

Benzydamine; Caffeine; Cytochrome P450; Flavin containing monooxygenase; Human liver microsomes; N oxide

Indexed keywords

BENZYDAMINE; CAFFEINE; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 3A4; DEBRISOQUINE 4 HYDROXYLASE; DIMETHYLANILINE MONOOXYGENASE; ETHOXYRESORUFIN DEETHYLASE; PARAXANTHINE; PHENACETIN O DEETHYLASE; THEOPHYLLINE;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ISOLATION; FLUORESCENCE; HUMAN; HUMAN CELL; METABOLIC BALANCE; OXYGENATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TISSUE SPECIFICITY; ULTRAVIOLET RADIATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZYDAMINE; CAFFEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; MICROSOMES, LIVER; OXIDATION-REDUCTION; OXYGENASES;

EID: 0033770639     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00265.x     Document Type: Article

References (13)

1. Pharmacogenetics of antidepressants: Clinical aspects
2. In vitro and in vivo drug interactions involving human CYP3A
3. Warfarin-fluconazole II. A metabolically based drug interaction: In vivo studies
4. Use of probe drugs as predictors of drug metabolism in humans
5. Transformation Enzymes. Oxidative; Non-P450
6. Missense mutation in flavin-containing monooxygenase gene FMO3 underlies fish-odour syndrome
7. Phenotyping of flavin-containing monooxygenase using caffeine metabolism and genotyping of FMO3 in a Korean population
8. Estimation of flavin-containing monooxygenase activity in intact hepatocyte monolayers of rat, hamster, rabbit, dog and human by using N-oxidation of benzydamine
9. Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 isoforms: Selective catalysis by FMO3
10. Identification of enzymes involved in the metabolism of atrazine, terbuthylazine, ametryne and terbutryne in human liver microsomes
11. Allelic variants of P4502C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity and prochiral selectivity of the wild-type and 1359L mutant forms
12. The use of caffeine as a metabolic probe for human drug-metabolizing enzymes
13. Pharmacokinetics of benzydamine