Anti-tumor potential of bisphosphonates

Medizinische Klinik

Volumn 95, Issue SUPPL. 2, 2000, Pages 23-28

  Green, J R ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Angiogenesis; Apoptosis; Bisphosphonates; Bone metastases; Cytotoxicity; Metastases; Zoledronic acid; ZOMETA

Indexed keywords

ALENDRONIC ACID; ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; GROWTH FACTOR; IBANDRONIC ACID; PACLITAXEL; PAMIDRONIC ACID; RISEDRONIC ACID; TAMOXIFEN; ZOLEDRONIC ACID;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BONE ATROPHY; CANCER INHIBITION; CELL ADHESION; CELL INVASION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; MITOSIS INHIBITION; TUMOR; TUMOR CELL;

ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; BONE RESORPTION; DIPHOSPHONATES; HUMANS; TUMOR CELLS, CULTURED;

EID: 0033766327     PISSN: 07235003     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (36)

1. In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates
2. Expression of bone matrix proteins in human breast cancer: Potential roles in microcalcification formation and in the genesis of bone metastases
3. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
4. Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices
5. Developments in the therapeutic applications of bisphosphonates
6. Alendronate reduces adhesion of human osteoclast-like cells to bone and bone-coated surfaces
7. Geranylgeranylated proteins regulate osteodast formation, morphology, function and survival: Inhibition of prenylation by bisphosphonates and GGTI-298
8. Zoledronate is a potent inhibitor of myeloma cell growth and secretion of IL-6 and MMP-1 by the tumoral environment
9. Cancer and bone
10. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis
11. Effect of the bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system
12. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
13. Zoledronic acid induces apoptosis of breast cancer cells in vitro - Evidence for additive and synergistic effects with taxol and tamoxifen
14. Protective effects of a prophylactic treatment with the bisphosphonate 3-amino-1-hydroxypropane-1,1-bisphosphonic acid on the development of tumor osteopathies in the rat: Experimental studies with the Walker carcinosarcoma 256
15. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
16. Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of 28 human breast carcinoma cells to bone
17. Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro
18. Bisphosphonates: Mechanisms of action
19. Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes
20. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
21. Inhibition of antigen-presenting cell function by alendronate in vitro
22. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
23. Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice
24. Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure
25. Pamidronate reduces IL-6 production by bone marrow stroma from multiple myeloma patients
26. Bisphosphonates induce apoptosis in human breast cancer cells
27. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway
28. Bisphosphonates induce apoptosis in human myeloma cell lines: A novel antitumour activity
29. Alendronate blocks TFG-β1 stimulated collagen 1 degradation by human prostate PC-3 ML cells
30. Effects of alendronate and taxol on PC-3ML cell bone metastases in SCID mice
31. Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines
32. MMP inhibition and down-regulation by bisphosphonates
33. Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro
34. Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat
35. Zoledronic acid (Zomelita®), a potent inhibitor of bone resorption, inhibits proliferation and induces apoptosis in human endothelial cells in vitro and is anti-angiogenic in murine growth factor implant model
36. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2