Failure of evidence-based medicine in the treatment of hypertension in older patients

Journal of General Internal Medicine

Volumn 15, Issue 10, 2000, Pages 702-709

  Knight, Eric L ^a,b   Glynn, Robert J ^a   Levin, Raisa ^a   Ganz, David A ^a   Avorn, Jerry ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Evidence based medicine; Hypertension; Older patients

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; THIAZIDE DIURETIC AGENT;

AGED; ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CHOICE; DRUG COST; ELDERLY CARE; EVIDENCE BASED MEDICINE; FEMALE; HEART INFARCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRACTICE GUIDELINE; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS;

AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; DRUG UTILIZATION REVIEW; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; HYPERTENSION; LOGISTIC MODELS; MALE; MEDICAID; NEW JERSEY; OUTCOME ASSESSMENT (HEALTH CARE); PHYSICIAN'S PRACTICE PATTERNS; UNITED STATES;

EID: 0033764535     PISSN: 08848734     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1497.2000.91020.x     Document Type: Article

References (34)

1. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
2. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure
3. The 1988 report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure
4. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group
5. Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension)
6. Medical Research Council trial of hypertension in older adults: Principal results. MRC Working Party
7. Trends in antihypertensive drug use in the United States
8. Temporal patterns of antihypertensive medication use among older adults, 1989 through 1992. An effect of the major clinical trials on clinical practice?
9. Trends in pharmacologic management of hypertension in the United States
10. Trends in medications choices for hypertension in the elderly: The decline of the thiazides
11. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group
12. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators
13. Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria
14. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group
15. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction
16. A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results
17. Medicaid data as a resource for epidemiologic studies: Strengths and limitations
18. Use of Medicaid data for pharmacoepidemiology
19. Health outcomes associated with antihypertensive therapies used as first-line agents
20. Are β-blockers efficacious as first-line therapy for hypertension in the elderly?
21. Randomized double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-EUR) Trial Investigators
22. Effect of long-acting and short-acting calcium antagonists on cardiovascular outcomes in hypertensive patients
23. The effect of nisolodipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension
24. The risk of myocardial infarction associated with antihypertensive therapies
25. Influences of educational interventions and adverse news about calcium-channel blockers on first-line prescribing of antihypertensive drugs to elderly people in British Columbia
26. Prevalence, clinical correlates, and treatment of hypertension in elderly nursing home residents. SAGE (Systematic Assessment of Geriatric Drug Use via Epidemiology) Study Group
27. Single-drug therapy for hypertension in men. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents
28. Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus: A 7-year follow-up study
29. Knowledge and practices of generalist and specialist physicians regarding drug therapy for acute myocardial infarction
30. Underutilization of beta-blockers in older patients with prior myocardial infarction or coronary artery disease in an academic, hospital-based geriatrics practice
31. Beta blocker use in the treatment of community hospital patients discharged after myocardial infarction
32. The accuracy of Medicare's hospital claims data: Progress has been made, but problems remain
33. Cost-minimization and the number needed to treat in uncomplicated hypertension