Expression of the endothelin-converting enzyme-1 isoforms in endothelial cells

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Muller, L ^a   Valdenaire, O ^a   Barret, A ^a   Korth, P ^a   Pinet, F ^a   Corvol, P ^a   Tougard, C ^a  

^a l'alimentation et l'Environnement   (France)

Author keywords

Electron microscope immunocytochemistry; Endothelial cell line; Endothelin converting enzyme (ECE); Isoform

Indexed keywords

DITHIOTHREITOL; ENDOTHELIN; ENDOTHELIN CONVERTING ENZYME; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ARTICLE; ENDOCYTOSIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

EID: 0033761984     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00007     Document Type: Article

References (21)

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3. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum
4. Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11
5. Isoforms of endothelin-converting enzyme: Why and where?
6. A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter. Molecular cloning and characterization
7. Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)
8. Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells
9. Human endothelin-converting enzyme (ECE-1): Three isoforms with distinct subcellular localizations
10. Constitutive lysosomal targeting and degradation of bovine endothelin-converting enzyme-1a mediated by novel signals in its alternatively spliced cytoplasmic tail
11. The N-terminal segment of endothelin-converting enzyme (ECE)-1b contains a di-leucine motif that can redirect neprilysin to an intracellular compartment in Madin-Darby canine kidney (MDCK) cells
12. Two di-leucine-based motifs account for the different subcellular localizations of the human endothelin-converting enzyme (ECE-1) isoforms
13. Permanent cell line expressing human factor VIII-related antigen established by hybridization
14. Endothelin-1 is expressed and released by a human endothelial hybrid cell line (EA.hy 926)
15. Effects of phosphoramidon in endothelial cell cultures on the endogenous synthesis of endothelin-1 and on conversion of exogenous big endothelin-1 to endothelin-1
16. Identification and characterization of endothelin converting activity from EAHY 926 cells: Evidence for the physiologically relevant human enzyme
17. A permanent human cell line (EA.hy926) preserves the characteristics of endothelin converting enzyme from primary human umbilical vein endothelial cells
18. A simple method for isolating human endothelin converting enzyme free from contamination by neutral endopeptidase 24.11
19. Construction, expression and characterization of a soluble form of human endothelin-converting-enzyme-1
20. Anti-peptide antibodies specific to rat endothelin-converting enzyme-1 isoforms reveal isoform localisation and expression
21. Endothelin-converting enzyme: Ultrastructural localization and its recycling from the cell surface