Differential pattern of endothelin-1-induced inotropic effects in right atria and left ventricles of the human heart

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5, 2000, Pages 564-569

  Dhein, S ^a   Giessler, C ^a   Wangemann, T ^a   Silber, R E ^a   Zerkowski, H R ^a   Brodde, O E ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Endothelin; ET(A) receptor ET(B) receptor; Human heart

Indexed keywords

ADENYLATE CYCLASE; BOSENTAN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN RECEPTOR; FORSKOLIN; INOSITOL PHOSPHATE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE;

ADULT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HEART ATRIUM CONTRACTION; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTION; HEART MUSCLE CONTRACTILITY; HEART RIGHT ATRIUM; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; INOTROPISM; MALE; PRIORITY JOURNAL;

EID: 0033760328     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200011000-00004     Document Type: Article

References (32)

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
2. Endothelins: Molecular biology, biochemistry, pharmacology, physiology and pathophysiology
3. Endothelin is a positive inotropic agent in human and rat heart in vitro
4. Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium
5. Functional and autoradiographic evidence for endothelin-1 receptors on human and rat heart cardiac myocytes
6. Influence of endothelin-1 on human atrial myocardium - Myocardial function and subcellular pathways
7. Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and failing myocardium
8. Evidence of endothelin-1-mediated vasoconstriction in severe chronic heart failure
9. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
10. Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure
11. Endothelin in congestive heart failure
12. Is there a role for endothelin in the natural history of heart failure?
13. Integrated cardiac, renal, and endocrine actions of endothelin
14. International Union of Pharmacology nomenclature of endothelin receptors
15. Characterization and localization of endothelin receptor subtypes in human atrioventricular conducting system and myocardium
16. Endothelin receptors in the human coronary artery, ventricle and atrium
17. Endothelin receptors in the failing and non-failing human heart
18. Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure
19. Coupling of the type A endothelin receptor to multiple responses in adult rat cardiac myocytes
20. Endothelin ET(A)-receptors couple to inositol phosphate formation and inhibition of adenylate cyclase in human right atrium
21. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
22. BQ-123, a selective endothelin ET(A)-receptor antagonist
23. Biochemical and pharmacological profile of a potent and selective endothelin B receptor antagonist, BQ-788
24. Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: Blockade with SB 209670
25. Inositol phosphates and cell signalling
26. +-exchanger
27. Muscarinic receptors in the failing human heart
28. 2+ in SK-N-MC cells
29. Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure
30. Alterations of β-adrenoceptor-G-protein-regulated adenylylcyclase in heart failure
31. Modulation of adrenergic receptors and G-transduction proteins in failing human ventricular myocardium
32. Increase of G(i) alpha in human hearts with dilated but not ischemic cardiomyopathy