AMP-activated protein kinase: Possible target for treatment of type 2 diabetes

Diabetes Technology and Therapeutics

Volumn 2, Issue 3, 2000, Pages 441-448

  Winder, W W ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE DERIVATIVE; ADENOSINE PHOSPHATE; CREATINE PHOSPHATE; GLUCOSE TRANSPORTER; PROTEIN KINASE;

ANIMAL EXPERIMENT; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; EXERCISE; GENETIC TRANSCRIPTION; GLUCOSE TRANSPORT; HUMAN; INSULIN SENSITIVITY; MUSCLE CONTRACTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REVIEW;

ADENOSINE MONOPHOSPHATE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; DIABETES MELLITUS, TYPE 2; ENZYME ACTIVATION; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; MONOSACCHARIDE TRANSPORT PROTEINS; MULTIENZYME COMPLEXES; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN-SERINE-THREONINE KINASES; RATS; RIBONUCLEOTIDES;

EID: 0033759381     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/15209150050194305     Document Type: Review

References (49)

1. Report of the expert committee on the diagnosis and classification of diabetes mellitus
2. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
3. The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
4. Regulation of glucose transport into skeletal muscle
5. Exercise regulation of glucose transport in skeletal muscle
6. Exercise, glucose transport, and insulin sensitivity
7. Molecular basis of insulin-stimulated GLUT4 vesicle trafficking
8. AICA ribosicle increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
9. Evidence for 5'-AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport in skeletal muscle
10. AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes
11. Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus
12. Exercise in the management of non-insulin-dependent diabetes mellitus
13. Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body
14. Effect of 7-10 days of cycle ergometer exercise on skeletal muscle GLUT4 protein content
15. Rapid reversal of adaptive increases in muscle GLUT-4 and glucose transport capacity after training cessation
16. Exercise induces a transient increase in transcription of the GLUT-4 gene in skeletal muscle
17. Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle
18. Regulatory elements in the insulin-responsive glucose transporter (GLUT-4) gene
19. Localization of exercise- and denervation-responsive elements in the mouse GLUT4 gene
20. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle
21. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
22. Effects of exercise on glucose tolerance and insulin resistance
23. The effects of physical activity on health and disease
24. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus
25. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes
26. Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 (non-insulin-dependent) diabetes patients
27. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM
28. Gene expression of GLUT-4 in skeletal muscle from insulin-resistant patients with obesity, IT, GDM, and NIDDM
29. Evidence for defects in the trafficking and translocation of GLUT-4 glucose transporters in skeletal muscle as a cause of human insulin resistance
30. Exercise training reverses insulin resistance in muscle by enhanced recruitment of GLUT-4 to the cell surface
31. The AMP-activated protein kinase. Fuel gauge of the mammalian cell?
32. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
33. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
34. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
35. Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase
36. Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated protein kinase in skeletal muscle
37. Effect of tension on contraction-induced glucose transport in rat skeletal muscle
38. Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase
39. The mitochondrial carnitine palmitoyltransferase system from concept to molecular analysis
40. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase
41. Effect of AMPK activation on muscle glucose metabolism in conscious rats
42. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
43. Metabolic stress and glucose transport
44. 5'-Activated protein kinase activation causes GLUT4 translocation in skeletal muscle
45. The effect of AMP-activated protein kinase (AMPK) stimulation on whole body glucose metabolism in awake lean and Zucker diabetic fatty (ZDF) rats
46. Pharmacological activation of 5'AMP-activated protein kinase (AMPK) in vivo acutely decreases blood glucose and chronically increases GLUT4 in normal and diabetic animals
47. Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
48. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
49. Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro