IL-12 and IL-2 potentiate the in vitro tumor-specific activity of peripheral blood cells from cervical cancer patients

Journal of Experimental and Clinical Cancer Research

Volumn 19, Issue 3, 2000, Pages 367-374

  Verma, V ^a   Sharma, V ^a   Shrivastava, S K ^a   Nadkarni, J J ^a  

^a TATA MEMORIAL HOSPITAL   (India)

Author keywords

Adhesion molecules; IL 12; IL 2; LAK; NC

Indexed keywords

CD45 ANTIGEN; CELL ADHESION MOLECULE; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 7; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ADULT; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PATIENT; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOKINE ACTIVATED KILLER CELL; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; TUMOR CELL; UTERINE CERVIX CANCER;

ADULT; ANTIGENS, SURFACE; CELL DIVISION; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTERLEUKIN-12; INTERLEUKIN-2; K562 CELLS; KILLER CELLS, LYMPHOKINE-ACTIVATED; KINETICS; MIDDLE AGED; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0033759232     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. The status of human papillomavirus and tumor suppressor genes p53 and p16 in carcinoma of uterine cervix from India
2. Cervix
3. Interleukin-2, hope in cases of cisplatin-resistant tumors
4. Lymphokines and cytokines as cancer treatment: Immunotherapy realised
5. Prospects for cytokines in human immunotherapy
6. Natural killer and antibody dependent cellular cytotoxicity in cervical carcinoma patients
7. Down-regulation of CD25 expression on the surface of activated tumor infiltrating lymphocytes in human cervical carcinoma
8. Dual effect of cytokines in regulation of MHC-unrestricted cell mediated cytotoxicity
9. Enhancing effect of natural killer cell stimulation factor(NKCF/interleukin-12) on cell mediated cytotoxicity against tumor derived and virus infected cells
10. Transcription factor activation in LAK cells and lymphocytes from patients receiving IL-2 immunotherapy
11. Natural killer cells and cancer
12. Interleukin-12: A cytokine produced by antigen presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
13. Proinflammatory and immunoregulatory functions of IL- 12
14. Immunology of IL-12
15. Administration of IL-12 with pulse IL-2 and rapid and complete eradication of murine renal carcinoma
16. Human Papilloma viruses and cervical cancer
17. Separation of leukocytes from blood and bone marrow
18. Augmented human-tumor cytolytic activity of PBLs and cells from mixed lymphocyte/tumor culture activated by Il-12 plus IL- 2 and the phenotypic characterization of the cells in patients with advanced carcinoma
19. Cancer immunotherapy of established tumors with IL-12: Effective delivery by genetically engineered fibroblasts
20. Development of four donor specific phenotypes in human long-term LAK cell cultures
21. Augmentation of cisplatin cytotoxicity using cytokines on cervical carcinoma cell lines
22. IL-15 effectively potentiates the in vitro tumor specific activity and proliferation of peripheral blood T cells isolated from glioblastoma patients
23. Generation of cytokine induced killer cells using exogenous IL-2, IL-7, IL- 12
24. Differential quantitative effects of IL-2 and IL-15 on cytolytic activity and proliferation by lymphocytes from patients receiving in vivo IL-2 therapy
25. Comparative analysis of IL-15 and IL-2 for induction of Killer activity of type 2 cytokine production by mononuclear cells from lung cancer patients
26. Roots and perspectives of contemporary papillomavirus research
27. Lymphokine activated killer cells and Interleukin-2 production in patients with cervical carcinoma
28. Generation of memory CD4+, CD8+, CD45RO+ and CD16-lymphocytes activated with IL-2, IFN-γ and TNF-α with specific cytotoxicity against autologous cervical cancer cells in a mixed leukocyte-tumor cell culture
29. Cytokine modulation of immune defenses in cervical cancer
30. Generation of killer activity by IL-12 of mononuclear cells in malignant pleural effusions due to lung cancer
31. IL-12 mediated tumoricidal activity of patient lymphocytes in an autologous in vitro ovarian cancer assay system
32. IL-12 synergises with IL-2 to induce lymphokine activated cytotoxicity and perforin and granzyme gene expression in fresh human NK cells
33. Interleukin-12 induced cytolytic activity in lymphocytes from recipients of autologous and allogenic stem cell transplants
34. The in vitro effects of IL-12 upon tumor-infiltrating lymphocytes derived from renal cell carcinoma
35. IL-2 and IL-7 augment the cytolytic activity and expand the antitumor killing spectrum of a CD3-induced activated killer cells: Potential use in the immunotherapy of non-immunogenic tumors
36. Co-operation between CD44 and LFA-1/CD11-a adhesion receptors in LAK cell cytotoxicity
37. Oncolytic activity of NK cells against SW756 squamous cervical carcinoma cell lines: Role of IFN α and γ CD54 adhesion molecule in oncolysis