Studies on anti-MRSA parenteral cephalosporins II. Synthesis and antibacterial activity of 7 β-[2-(5-Amino-1,2,4-thiadiazol-3-yl)- 2(Z)-alkoxyiminoacetamido]-3(substituted imidazo[1,2-b] pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and related compounds

Journal of Antibiotics

Volumn 53, Issue 10, 2000, Pages 1071-1085

  Ishikawa, T ^a   Kamiyama, K ^a   Matsunaga, N ^a   Tawada, H ^a   Iizawa, Y ^a   Okonogi, K ^a   Miyake, A ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 CYCLOPENTYLOXYIMINOACETAMIDO] 3 (3,6 DIAMINOIMIDAZO[1,2B]PYRIDAZINIUM 1 YL)METHYL 3 CEPHEM 4 CARBOXYLIC ACID; ANTIBIOTIC AGENT; CEFOZOPRAN; CEFOZOPRAN DERIVATIVE; CYCLOPENTANE DERIVATIVE; HYDROXYLAMINE; PENICILLIN BINDING PROTEIN; PHTHALIMIDE DERIVATIVE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0033756886     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.1071     Document Type: Article

References (16)

1. Studies on anti-MRSA parenteral cephalosporins: I. Synthesis and antibacterial activity of 7β-[2-(5-amino- 1,2,4-thiadiazol-3-yl)-2(Z)-hydroxyiminoacetamido]-3- (substituted cephem-4-carboxylates and related compounds
2. GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity
3. In vitro evaluation of E1077, a new cephalosporin with a broad anti-bacterial spectrum
4. Structure-activity relationships of cephalosporins having a (dimethylisoxazolidinio)vinyl moiety at their 3- position
5. CP6679, a new injectable cephalosporin: I. Synthesis and structure-activity relationships
6. β-Lactamase-stable penicillins. Synthesis and structure-activity relationships of (Z)-alkoxyimino penicillins; selection of BRL 44154
7. Synthesis and biological evaluation of a series of new parenteral optically active 3-[[(N-alkylpyridinium-4'-yl)thio]- methyl]-2-oxaisocephems
8. In vitro and in vivo antibacterial activities of OPC-20011, a novel parenteral broad-spectrum 2-oxaisocephem antibiotic
9. Preparation of acylaminopenicillins as antibacterial agents
10. Efficient preparation of (Z)-2- (5-amino-1,2,4-thiadiazol-3-yl)-2-[(fluoromethoxy)- imino]acetic acid
11. Preparation of 3- (pyrazoliomethyl)cephemcarboxylates as antibiotics
12. Preparation of crystalline cephalosporin derivatives
13. Synthesis of carbon-14 and deuterium labelled 3-nitro-6-propoxyimidazo[1,2-b]pyridazine - An antiparasitic agent
14. Preparation of 1,3,2-dioxaphospholes as catalysts and use in preparation of cephem carboxylates
15. Acetolysis of 3,3-disubstituted cyclobutyl tosylates