CYP3A4-V polymorphism detection by PCR-restriction fragment length polymorphism analysis and its allelic frequency among 199 Dutch Caucasians

Clinical Chemistry

Volumn 46, Issue 11, 2000, Pages 1834-1836

  Van Schaik, R H N ^a   De Wildt, S N ^a   Van Iperen, N M ^a   Uitterlinden, A G ^a   Van den Anker, J N ^a   Lindemans, J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DNA;

ARTICLE; CAUCASIAN; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ANALYSIS; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; NETHERLANDS; NORMAL HUMAN; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0033756276     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/46.11.1834     Document Type: Article

References (18)

1. The P450 superfamily: Update on new sequences, gene mapping, and recommended nomenclature
2. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
3. Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
4. Cytochrome P450 3A: Ontogeny and drug disposition
5. Use of midazolam as a human cytochrome P450 3A probe. I. In vitro-in vivo correlations in liver transplant patients
6. Intraindividual variability in the relative systemic availability of cyclosporin after oral dosing
7. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
8. Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control
9. CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity
10. Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4
11. Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: Ethnic distribution and implications for prostate cancer risk
12. Association of CYP3A4 genotype with treatment-related leukemia
13. Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients
14. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
15. Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5'-upstream regulatory region
16. Substrates of human hepatic cytochrome P450 3A4
17. More about: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
18. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4