Second-site suppressor mutations of inactivating substitutions at Gly247 of the tetracycline efflux protein, Tet(B)

Journal of Bacteriology

Volumn 182, Issue 22, 2000, Pages 6514-6516

  Saraceni Richards, C A ^a   Levy, S B ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; ASPARTIC ACID; BACTERIAL PROTEIN; GLYCINE; PROTEIN TET(B); TETRACYCLINE; TETRACYCLINE EFFLUX PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; GENE LOCATION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR GENE;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; GLYCINE; MUTATION; SUPPRESSION, GENETIC; TETRACYCLINE RESISTANCE;

EID: 0033754373     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.22.6514-6516.2000     Document Type: Article

References (23)

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5. + antiporter from Staphylococcus aureus: Mutagenesis and functional analysis of motif C
6. Structural features of the uniporter/symporter/antiporter superfamily
7. Interaction between residues Glu269 (helix VIII) and His322 (helix X) of the lactose permease of Escherichia coli is essential for substrate binding
8. Evidence that transmembrane segment 2 of the lactose permease is part of a conformationally sensitive interface between the two halves of the protein
9. Suppressor analysis of mutations in the loop 2-3 motif of lactose permease: Evidence that glycine-64 is an important residue for conformational changes
10. Functional importance and local environments of the cysteines in the tetracycline resistance protein encoded by plasmid pBR322
11. + antiporter
12. + antiporter as studied by site-directed chemical labeling
13. + antiporter
14. Nomenclature for new tetracycline resistance determinants
15. Major facilitator superfamily
16. An analysis of suppressor mutations suggests that the two halves of the lactose permease function in a symmetrical manner
17. Characterization of Glu126 and Arg144, two residues that are indispensable for substrate binding in the lactose permease of Escherichia coli
18. Evidence for interactions between helices 5 and 8 and a role for the interdomain loop in tetracycline resistance mediated by hybrid Tet proteins
19. Mutational analysis and molecular modelling of an amino acid sequence motif conserved in antiporters but not symporters in a transporter superfamily
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21. + translocation
22. + antiporter of Escherichia coli
23. + antiporter of Escherichia coli encoded by transposon Tn10: The structural resemblance and functional difference in the role of the duplicated sequence motif between hydrophobic segments 2 and 3 and segments 8 and 9