Endothelin-1 induces an endothelin-A-receptor-dependent and L-NAME-sensitive vasoconstriction in the isolated perfused guinea-pig kidney

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Duval, M ^a   D'Orleans Juste, P ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

BQ 123; BQ 788; Endothelin 1 (ET 1); IRL 1620; L NAME; Vasoconstriction

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR AGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ICOSANOID; INDOMETACIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE];

ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; GUINEA PIG; KIDNEY; NONHUMAN; PRIORITY JOURNAL; VASOCONSTRICTION;

EID: 0033753048     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00067     Document Type: Article

References (8)

1. 2 from the guinea-pig lung and nitric oxide from the rabbit kidney by a selective ET(B) receptor antagonist, BQ-788
2. Nitric oxide limits the eicosanoid-dependent brochoconstriction and hypotension induced by endothelin-1 in the guinea-pig
3. Endothelin: A potent renal and systemic vasoconstrictor peptide
4. Effectiveness of enalapril versus nifidipine to antagonize blood pressure and the response to ET-1 in humans
5. 9, Ala(11,15)]-endothelin-1(8-21), IRL 1620, for the ETB receptor
6. Endothelin-1 induces vasoconstriction and prostacyclin release via the activation of endothelin ETA receptors in the perfused rabbit kidney
7. Effects of endothelin-1 and endothelin-3 on the release of prostanoids from isolated perfused rat kidney
8. Endothelin-1 releases eicosanoids from rabbit isolated perfused kidney and spleen