Production of podophyllotoxin from Podophyllum hexandrum: A potential natural product for clinically useful anticancer drugs

Cytotechnology

Volumn 34, Issue 1-2, 2000, Pages 17-26

  Giri, Archana ^a   Lakshmi Narasu, M ^a  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Etoposide; Metabolic engineering; Podophyllotoxin; Podophyllum hexandrum; Teniposide; Tissue culture

Indexed keywords

ANTIVIRAL ACTIVITY; CANCER CELL; CYTOTOXICITY; DRUG MANUFACTURE; ENDANGERED SPECIES; ETOPOSIDE; MEDICINAL PLANT; PODOPHYLLOTOXIN; TENIPOSIDE;

BERBERIDACEAE; PODOPHYLLUM; SINOPODOPHYLLUM HEXANDRUM;

EID: 0033744225     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008138230896     Document Type: Article

References (68)

1. Oral etopoide and pallitative treatment for small cell lung cancer
2. Somatic embryogenesis in tissue cultures of Podophyllum hexandrum
3. Natural product drug discovery and development: New perspectives on international collaboration
4. On the podophyllotoxins of root cultures of Linum flavum
5. Simultaneous quantification of etoposide and its catechol metabolite in human plasma using high-performance liquid chromatography with electrochemical detection
6. The clinical pharmacology of etoposide and teniposide
7. Antineoplastic agents
8. Clinical pharmacology of cancer chemotherapy
9. Experimental podophyllotoxin (bajiaolian) poisoning: I. Effects on the nervous system
10. Antiviral activity of lignans
11. Natural products in drug discovery and development
12. Podophyllotoxins: Current status and recent developments
13. Tumour inhibitors from plants
14. Determination of the aryltetralin lignan content of podophyllum resins and roots/rhizomes
15. Botanical sources differentiation of Podophyllum resin by high performance liquid chromatography
16. Chromosomal changes in Chinese hamster AAB cells caused by podophyllin, a common treatment for genital warts
17. Neurologic manifestations of podophyllin toxicity
18. Comprehensive synthetic route to eight diastereomeric Podophyllum lignans
19. Biotransformations
20. Transgenic hairy roots: Recent trends and applications
21. Antitumour and radioprotective action of Podophyllum hexandrum
22. Treatment of HIV-related hairy leukoplakia with podophyllum resin 25% solution
23. Drug delivery of anticancer agents: Water soluble 4-poly ethylene glycol derivatives of the lignan, podophyllotoxin
24. Conservation of medicinal plant resources
25. Hypoglycemic plants: A review
26. Production of tumour - Inhibitory lignans in callus cultures of Podophyllum hexandrum
27. Etoposide and teniposide. Biosynthesis, metabolism and clinical pharmokinetics
28. The biological activities of podophyllotoxin compounds
29. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum
30. Formation of podophyllotoxins by Podophyllum peltatum tissue cultures
31. Growth and podophyllotoxin production in callus tissues of Podophyllum peltatum
32. Biosynthetic relationship of aryltetralin lactone lignans to dibenzylbutyrolactone lignans
33. Podophyllotoxin intoxication: Toxic effects of Bajiaolian in herbal therapeutics
34. Condyloma acuminata
35. Compendium of pharmaceuticals and specialties
36. Alkaloid biosynthesis- The basis for metabolic engineering of medicinal plants
37. Biological activities of lignans
38. Noncervical human papillomavirus genital infections
39. Pharmacokinetics of intrapleural versus intravenous etoposide (VP-16) and teniposide (VM-26) in patient with malignant pleural effusion
40. Establishment of hairy root cultures of Linum flavum producing the lignan 5-methoxy podophyllotoxin
41. Variation in podophylloresin and podophyllotoxin contents in different populations of Podophyllum hexandrum
42. Carmustine, etoposide, cytarabine and melphalan as a preparative regimen for allogeneic transplantation for high-risk malignant lymphoma
43. Phase I clinical and pharmacokinetic trial of the podophyllotoxin derivative NK611 administered as intravenous short infusion
44. Successful peripheral blood stem cell mobilization with etoposide (VP-16) in patients with relapsed or resistant lymphoma who failed cyclophosphamide mobilization
45. Effects of VM-26 (teniposide), a specific inhibitor of type Iitopoisomerase, on SV-40 DNA replication in vivo
46. Permanent cell cycle arrest in asynchronously proliferating normal human fibroblasts treated with doxorubicin or etoposide but not camptothecin
47. Podophyllin
48. Vinca alkaloids and epipodophyllotoxins
49. Seed production and seedling establishment in the Mayapple, Podophyllum peltatum L
50. Escalating sequential high-dose carboplatin and etoposide with autologous marrow support in children with relapsed solid tumours
51. Etoposide phosphate: What, why, where, and how?
52. From podophyllotoxin glucoside to etoposide
53. From the chemical and biological route from podophyllotoxin glucoside to etoposide, ninth Cain memorial award lecture
54. 9-Deoxopodophyllotoxin derivatives as anti-cancer agents
55. Plant drugs: Emerging areas of modem drug research
56. Antiproliferative effects on human peripheral blood mononuclear cells and inhibition of in vitro immunoglobulin synthesis by podophyllotoxin (CPH86) and by semisynthetic lignan glycosides (CPH82)
57. Preliminary observations for a new treatment in children with primary intracranial yolk sac tumour or embroynal carcinoma. Report of five cases
58. Detection and identification of podophyllotoxin produced by cell cultures derived from Podophyllum hexandrum Royle
59. On the improvement of the podophyllotoxin production by phenylpropanoid precursor feeding to cell cultures of Podophyllum hexandrum Royle
60. Cyclodextrins as a useful tool for bioconversions in plant cell biotechnology
61. Etoposide in the treatment of six children with langerhans cell histiocytosis (histiocytosis X)
62. Cinnamyl-alcohol dehydrogenase, a molecular marker specific for lignin synthesis: cDNA cloning and MRNA induction by fungal elicitor
63. Podophyllin 0.5% or 2.0% v podophyllotoxin 0.5% for the self treatment of penile warts: A double blind randomized study
64. Secondary acute myeloid leukemia in children with lymphoblstic leukemia treated with etoposide
65. Increased podophyllotoxin production in Podophyllum hexandrum cell suspension cultures after feeding coniferyl alcohol as a β-cyclodextrin complex
66. Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, di-, and trisubstituted aniline-4'-O-demethylpodophyllotoxin and related compounds with improved pharmacological profiles