Glucocorticoids enhance IgE synthesis. Are we heading towards new paradigms?

Clinical and Experimental Allergy

Volumn 30, Issue 11, 2000, Pages 1499-1505

  Salvi, S S ^a   Babu, K S ^a   Holgate, S T ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; DEXAMETHASONE; GLUCOCORTICOID; HISTAMINE; HYDROCORTISONE; IMMUNOGLOBULIN E; LEUKOTRIENE; PREDNISOLONE;

ALLERGIC ASTHMA; CROSS LINKING; CYTOKINE PRODUCTION; DRUG EFFECT; HISTAMINE RELEASE; HUMAN; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

ANTIBODIES, ANTI-IDIOTYPIC; ASTHMA; GLUCOCORTICOIDS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E;

EID: 0033708984     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00990.x     Document Type: Review

References (69)

1. Association of asthma with serum IgE levels and skin-test reactivity to allergens
2. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children
3. Total arid specific IgE in serum, bronchial lavage and bronchoalveolar lavage of asthmatic patients
4. Ragweed-specific antibodies in bronchoalveolar lavage fluids and serum before and after segmental lung challenge: IgE and IgA associated with eosinophil degranulation
5. Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: Inhibition by a non-anaphylactogenic anti-IgE antibody
6. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway
7. Interleukin-4-5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines
8. Glucocorticoids in T cell Development and Function
9. Skin reactivity to codeine and histamine during prolonged corticosteroid therapy
10. Long-term oral corticosteroid therapy does not alter the results of immediate-type allergy skin prick tests
11. Hydrocortisone enhances allergen-specific IgE production by peripheral blood mononuclear cells from atopic patients with high serum allergen-specific IgE levels
12. Effect of hydrocortisone on spontaneous IgE and IgG4 production in atopic patients
13. Corticosteroid effect on immunoglobulins
14. The effects of acute corticosteroid therapy for asthma on serum immunoglobulin levels
15. In vivo effects of glucocorticoids on IgE production
16. Allergic breakthrough after antigen sensitization: Height of IgE synthesis is temporally related to diurnal variation in endogenous steroid production
17. Effects of cyclosporine and dexamethasone on IgE antibody response in mice, and on passive cutaneous anaphylaxis in the rat
18. Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone
19. Hydrocortisone enhances total IgE levels - But not the synthesis of allergen-specific IgE - In a monocyte-dependent manner
20. The role of T cells and the effect of hydrocortisone on interleukin-4-induced IgE synthesis by non-T cells
21. Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes
22. Molecular mechanisms of IgE regulation
23. Effect of dexamethasone on de novo IgE synthesis by human blood lymphocytes
24. Immunoglobulin production induced in vitro by glucocorticoid hormones: T cell-dependent stimulation of immunoglobulin production without B cell proliferation in cultures of human peripheral blood lymphocytes
25. Effect of hydrocortisone on immunoglobulin synthesis and secretion by human peripheral lymphocytes in vitro
26. IgE synthesis by chronic lymphocytic leukemia cells
27. Efficacy and safety of inhaled corticosteroids in asthma. Report of a workshop held in Eze, France, October 1992
28. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma
29. Prevalence and severity of childhood asthma and allergic sensitisation in seven climatic regions of New South Wales
30. Sensitization to inhaled allergens as a risk factor for asthma and allergic diseases in Chinese population
31. Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia
32. Current allergic asthma and rhinitis: Diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from 8329 randomized adults from the SAPALDIA Study. Swiss Study on Air Pollution and Lung Diseases in Adults
33. Prevalence of atopy, asthma symptoms and diagnosis, and the management of asthma: Comparison of an affluent and a non-affluent country
34. Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC)
35. Immunoglobulin E and allergic disease in africa
36. Bronchial asthma in the Nigerian savanna region. A clinical and laboratory study of 106 patients with a review of the literature on asthma in the tropics
37. Parasites and asthma in Tanzanian children
38. How much asthma is really attributable to atopy?
39. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma
40. Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes
41. Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness
42. Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness
43. Active anaphylaxis in IgE-deficient mice
44. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
45. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects
46. Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response
47. Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects
48. Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis
49. Corticosteroid (CS) withdrawal in a study of recombinant humanised monoclonal antibody to IgE (rhu mAB-E25)
50. Treatment of allergic-asthma with monoclonal anti-IgE antibody. Rhumab-E25 Study Group
51. Treatment of allergic asthma with monoclonal anti-IgE antibody
52. IgE in asthma and atopy: Cellular and molecular connections
53. Regulation of IgE production from human mononuclear cells by beta 2-adrenoceptor agonists
54. Role of cyclic AMP in the modulation of IgE production by the beta 2-adrenoceptor agonist, fenoterol
55. Functional interaction between beta 2-adrenoceptor agonists and interleukin-4 in the regulation of CD23 expression and release and IgE production in human
56. Isotype-specific regulation of human lymphocyte production of immunoglobulins by sustained exposure to vasoactive intestinal peptide
57. Cholera toxin promotes B cell isotype switching by two different mechanisms. cAMP induction augments germ-line Ig H-chain RNA transcripts whereas membrane ganglioside GM1-receptor binding enhances later events in differentiation
58. Prostaglandin E2 Promotes IL-4-Induced Ige Igg1 Synthesis
59. Effect of cyclic AMP-elevating agents on human spontaneous IgE synthesis in vitro
60. Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy
61. Sublingualswallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: A double-blind, placebo-controlled study
62. Effect Rush Immunotherapy (RIT) Hymenoptera
63. Immunological changes associated with a successful outcome of pollen immunotherapy
64. Monitoring allergen immunotherapy of pollen-allergic patients: The ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome
65. Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma
66. Regulatory effect of hydrocortisone on the in vitro synthesis of IgE by human lymphocytes
67. Influence of cytokines and cellular interactions on the glucocorticoid-induced Ig (E, G, A, M) synthesis of peripheral blood mononuclear cells
68. Effect of in vitro irradiation and cell Cycle-inhibitory drugs on the spontaneous human IgE synthesis in vitro
69. Enhancement of in vitro spontaneous IgE production by topical steroids in patients with atopic dermatitis