The ocular pharmacokinetics of ketanserin and its metabolite, ketanserinol, in albino rabbits

Journal of Ocular Pharmacology and Therapeutics

Volumn 16, Issue 5, 2000, Pages 481-495

  Schoenwald, R D ^a   Zhu, J ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETANSERIN; KETANSERINOL; SEROTONIN 2 ANTAGONIST;

ALBINISM; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CILIARY BODY; CONJUNCTIVA; CORNEA ENDOTHELIUM; CORNEA EPITHELIUM; CORNEA STROMA; DRUG ABSORPTION; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; IN VITRO STUDY; INTRAOCULAR PRESSURE; IRIS; LENS; MALE; NONHUMAN; RABBIT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCLERA;

EID: 0033694825     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2000.16.481     Document Type: Article

References (34)

1. 1-agonist 5-CT intraocular pressure in rabbits
2. Characterization of serotonin receptors in the iris + ciliary body of the albino rabbit
3. Effect of topical ketanserin administration on intraocular pressure
4. Effect of oral ketanserin administration on intraocular pressure in glaucomatous patients
5. Effects of ketanserin on intraocular pressure
6. Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit
7. Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit
8. The presence of serotonin (5-HT1) receptors negatively coupled to adenylate cyclase in rabbit and human iris-ciliary processes
9. 1(C) serotonin receptor binding
10. Mechanism of the ocular hypotensive action of ketanserin
11. 5-Hydroxytryptamine receptor subtypes
12. Serotonin modulators and cardiovascular/gastrointestinal diseases
13. Clinical pharmacokinetics of ketanserin
14. Determination of ketanserin in plasma by reversed-phase high-performance liquid chromatography
15. Determination of ketanserin and its major metabolite (reduced ketanserin) in human plasma by high-pressure liquid chromatography
16. Biopharmaceutical evaluation of ibufenac, and their hydroxyethoxy analogs in the rabbit eye
17. Effect of timolol on aqueous humor dynamics in the rabbit
18. Ocular ketone reductase distribution and its role in the metabolism of ocularly applied levobunolol in the pigmented rabbit
19. Penetration into the anterior chamber via the conjunctival/scleral pathway
20. Location of penetration and metabolic barriers to levobunolol in the corneal epithelium of the pigmented rabbit
21. Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
22. Importance of the noncorneal absorption route in topical ophthalmic drug delivery
23. Ocular penetration and pharmacokinetics of cefotaxime: An experimental study
24. Systemic absorption of Δ1-tetrahydrocannabinol after ophthalmic administration to the rabbit
25. Pharmacokinetic approach to equilibrium between ketanserin and ketanserinol
26. 3H hydrochloride
27. A physiologically based pharmacokinetic model for the intraocular distribution of pilocarpine in rabbits
28. Ocular and systemic bioavailability of ophthalmic flurbiprofen
29. Pharmacokinetics in ocular drug delivery
30. Ocular drug disposition
31. Disposition of levobunolol after an ophthalmic dose to rabbits
32. Ocular bioavailability and tissue distribution of [14C]ketorolac tromethamine in rabbits
33. Topical carbonic anhydrase inhibitors. III. Optimization model for corneal penetration of ethoxzolamide analogs