Effect of Serotonin and Its Antagonist (Ketanserin) on Intraocular Pressure in the Rabbit

Journal of Ocular Pharmacology

Volumn 3, Issue 4, 1987, Pages 279-290

  Krootila, Kari ^a   Palkama, Arto ^a   Uusitalo, Hannu ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

KETANSERIN; SEROTONIN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; FEMALE; INTRAOCULAR PRESSURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RABBIT; TOPICAL DRUG ADMINISTRATION;

ANESTHESIA; ANIMAL; AQUEOUS HUMOR; EYE; EYE PROTEINS; FEMALE; INJECTIONS; INJECTIONS, INTRAVENOUS; INTRAOCULAR PRESSURE; KETANSERIN; MALE; RABBITS; SEROTONIN; SEROTONIN ANTAGONISTS; SUPPORT, NON-U.S. GOV'T; SYMPATHECTOMY;

EID: 0023547656     PISSN: 87563320     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.1987.3.279     Document Type: Article

References (23)

1. Uusitalo, H., Lehtosalo, J., Laakso, J., Härkönen, M. and Palkama, A. Immunohistochemical and biochemical evidence for 5-hydroxytryptamine containing nerves in the anterior part of the eye. Exp. Eye Res. 35:671–675, 1982.
2. Klyce, S.D., Palkama, K.A., Härkönen, M., Marshaal, W.S., Huhtaniitty, S., Mann, K.P. and Neufeld, A.H. Serotonin stimulates chloride transport in the rabbit corneal epithelium. Invest. Ophthalmol. 23:181–192, 1982.
3. Palkama,A., Raij, K., Uusitalo, H., Lehtosalo, J. and Härkönen, M. (3-H)-Serotonin receptors in the anterior segment of the rabbit eye. An autoradiographic and biochemical study. Manuscript, 1987.
4. Neufeld, A.H., Ledgard, S.E., Jumblatt, M.M. and Klyce, S.D. Serotonin-stimulated cyclic AMP synthesis in the rabbit corneal epithelium. Invest. Ophthalmol. 23:193–198, 1982.
5. Neufeld, A.H., Ledgard, S.E. and Yoza, B.K. Changes in responsiveness of the beta-adrenergic and serotonergic pathways of the rabbit corneal epithelium. Invest. Ophthalmol. 24:527–534, 1983.
6. Leysen, J.E., Awouters, F., Kennis, L., Laduron, P.M., Vanden-berk, J. and Janssen, P.A.J. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 28:1015–1022, 1981.
7. Palkama, A., Uusitalo, H., Lehtosalo, J. and Raij, K. 5-HT nerves in the anterior segment of the eye and the effect of ketanserin on intraocular pressure (IOP) in normal and sympathectomized animals. Proc. Int. Soc. Eye Res. vol. 111:70, 1984.
8. Palkama, A., Uusitalo, H. and Lehtosalo, J. Effect of 5-HT antagonist and agonist on IOP in normal and sympathectomized eyes. Invest. Ophthalmol. Vis. Sci. 26 suppl.: 104, 1985.
9. Langham, M.E. The response of the pupil and intraocular pressure of conscious rabbits to adrenergic drugs following unilateral superior cervical ganglionectomy. Exp. Eye Res. 4:381–389, 1965.
10. Härkönen, M., Palkama, A. and Uusitalo, R. Functional dependence of the ciliary epithelium ATPase activity and intraocular pressure on the autonomic nervous system. Acta Physiol. Scand. 86:327–341, 1972.
11. Stjernschantz, J. Effect of parasympathetic stimulation on intraocular pressure, formation of the aqueous humour and outflow facility in rabbits. Exp. Eye Res. 22:639–645, 1976.
12. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randaal, R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275, 1951.
13. Hammond, B.R. and Bhattacherjee, P. Calibration of the Alcon applanation pneumatonograph and perkins tonometer for use in rabbits and cats. Curr. Eye Res. 3:1155–1158, 1984.
14. Perkins, E.S. Influence of the fifth cranial nerve on the intraocular pressure of the rabbit eye. Br. J. Ophthalmol. 41:257–300, 1957.
15. Jampol, L.M., Neufeld, A.H. and Sears, M.L. Pathways for the response of the eye to injury. Invest. Ophthalmol. 14:184–189, 1975.
16. Butler, J.M., Unger, W.G. and Hammond, B.R. Sensory mediation of the ocular response to neutral formaldehyde. Exp. Eye Res. 28:577–589, 1979.
17. Copeland, I.W. and Bentley, G.A. A possible central action of prazosin and ketanserin to cause hypotension. J. Cardiovasc. Pharmacol. 7:822–825, 1985.
18. Phillips, C.A., Mylecharane, E.J., Markus, J.K. and Shaw, J. Hypotensive actions of ketanserin in dogs: involvement of a centrally mediated inhibition of sympaahetic vascular tone. Eur. J. Pharmacol. 111:319–327, 1985.
19. Chang, F.W., Burke, J.A. and Potter, D.E. Mechanism of the ocular hypotensive action of ketanserin. J. Ocular Pharmacol. 1:137–147,1985.
20. Levene, R.Z. Mast cells and amines in normal ocular tissue. Invest. Ophthalmol. 1:531–543, 1962.
21. Smelser, G.K. and Silver, S. The distribution of mast cells in the normal eye. A method of study. Exp. Eye Res. 2:134–140, 1963.
22. Häppölä, O. 5-Hydroxytryptamine-immunoreactive neurons and nerve fibers in the superior cervical ganglion of the rat. (Neuroscience), submitted 1987.
23. Palkama, A., Uusitalo, H. and Lehtosalo, J. Innervation of the anterior segment of the eye: with special reference to functional aspects. In. Neurohistochemistry: Modern methods and applications, Panula, P., Päivärinta, H. and Soinila, S., eds. Alan R. Liss, Inc., New York, 1986, p. 587–615.