Investigation of a cluster of children with Down's syndrome born to mothers who had attended a school in Dundalk, Ireland

Occupational and Environmental Medicine

Volumn 57, Issue 12, 2000, Pages 793-804

  Dean, G ^a   Nevin, N C ^b   Mikkelsen, M ^c   Karadima, G ^d   Petersen, M B ^c,d   Kelly, M ^e   O'Sullivan, J ^f  

^a HEALTH RESEARCH BOARD   (Ireland)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c JOHN F KENNEDY INSTITUTE   (Denmark)

^d Institute of Child Health   (Greece)

^e St John of God's Drumcar   (Ireland)

^f OUR LADY OF LOURDES HOSPITAL   (Ireland)

Author keywords

Cluster; Down's syndrome; Maternal exposure

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CLUSTER ANALYSIS; DOWN SYNDROME; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; IRELAND; MALE; MATERNAL AGE; NONDISJUNCTION; NUCLEAR REACTOR; PREVALENCE; PRIORITY JOURNAL; QUESTIONNAIRE; RISK FACTOR;

ADULT; DOWN SYNDROME; FEMALE; HEALTH SURVEYS; HUMANS; INFANT, NEWBORN; IRELAND; MALE; MATERNAL AGE; MATERNAL EXPOSURE; NORTHERN IRELAND; PREVALENCE; RETROSPECTIVE STUDIES; SPACE-TIME CLUSTERING; TURNER SYNDROME;

EID: 0033694180     PISSN: 13510711     EISSN: None     Source Type: Journal    
DOI: 10.1136/oem.57.12.793     Document Type: Article

References (69)

1. An unusual cluster of babies with Down's syndrome born to former pupils of an Irish boarding school
2. An unusual cluster of babies with Down's syndrome
3. An unusual cluster of babies with Down's syndrome: Was it caused by the Windscale fire?
4. Role of radiation in aetiology of Down's syndrome
5. Non-disjunction in trisomy 21: Study of chromosomal heteromorphisms in 110 families
6. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
7. Linkage analysis of the human HMG14 gene on chromosome 21 using a GT dinucleotide repeat as polymorphic marker
8. Report and abstracts of the 5th International Workshop on Human Chromosome 21 Mapping 1994. Tsukuba, Japan, November 9-11, 1994
9. Use of short sequence repeat DNA polymorphisms after PCR amplification to detect the parental origin of the additional chromosome 21 in Down syndrome
10. Methods for studying recombination on chromosomes that undergo non-disjunction
11. Mitotic errors in somatic cells cause trisomy 21 in about 4.5% of cases and are not associated with advanced maternal age
12. Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum α-fetoprotein level
13. Growing interest in Turner syndrome
14. Turner syndrome: A cytogenetic and molecular study
15. Down's syndrome and maternal age
16. The epidemiology of Down syndrome in four counties in Ireland 1981-90
17. Registries of congenital anomalies: EUROCAT
18. The natural history of cytogenetically abnormal fetuses detected at midtrimester amneosentesis which are not terminated electively: New data and estimates of the excess and relative risk of late fetal death associated with 47, +21 and some other abnormal karyotypes
19. A sobering start for the cluster busters' conference
20. Twenty two years of cancer cluster investigations at the Centers for Disease Control
21. Cluster analysis and disease mapping: Why, when, and how? A step-by-step guide
22. Epidemiology of Hodkgin's disease
23. Significance of leukemia clusters
24. Use of computer simulation to evaluate a putative cluster of genetic or teratologic outcomes: Adjustment for 'multiple hypotheses' and application to a reported excess of Down's syndrome
25. Advanced maternal age and the risk of Down syndrome characterized by the meiotic stage of the chromosomal error: A population-based study
26. Parental origin and meiotic stage of non-disjunction in 139 cases of trisomy 21
27. An assessment of the radiological impact of the Windscale reactor fire, October 1957
28. Susceptible chiasmate configurations of chromosome 21 predispose to non-disjunction in both maternal meiosis I and meiosis II
29. ICPEMC Meeting Report No 3. Is the incidence of Down syndrome increasing?
30. Increased frequency of thyroid autoantibodies in mothers of patients with Down's syndrome
31. Autoantibodies and chromosomal aberrations
32. Thyroid antibodies as a risk factor for Down syndrome and other trisomies
33. Thyroid antibodies are not a risk factor for pregnancies with Down syndrome
34. Mongolism and other congenital abnormalities. An epidemiological study in Northamptonshire
35. Area relationship between incidences of infectious hepatitis and of the births of children with Down's syndrome nine months later
36. Viral hepatitis and Down's syndrome
37. Viral hepatitis and Down's syndrome
38. Some epidemiological aspects of Down's syndrome in British Columbia
39. Season of birth in Down's syndrome
40. Seasonal variation in the prevalence of Down syndrome at birth: A review
41. Is there evidence of clustering in Down syndrome?
42. Down's syndrome and maternal smoking in early pregnancy
43. Parity and Down syndrome
44. Effect of parity, gravidity, previous miscarriage, and age on risk of Down's syndrome: Population based study
45. Environmental determinants of birth defects prevalence
46. Study of Down syndrome in 238 942 consecutive births
47. Down's syndrome and related abnormalities in an area of high background radiation in coastal Kerala
48. Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. I. Prevalence of congenital malformations in newborns
49. A case-control study of congenital malformations and occupational exposure to low-level ionizing radiation
50. The prevalence at birth of congenital malformations in communities near the Hanford site
51. A case control study of trisomy 21 and maternal pre-conceptual radiography
52. Navajo birth outcomes in the Shiprock uranium mining area
53. Health of children born to medical radiographers
54. Outcome of reproduction in women irradiated for skin hemangioma in infancy
55. Effect of X-rays on chromosome 21 nondisjunction
56. Down's syndrome: Prevalence and ionising radiation in an area of north west England 1957-91
57. Chromosome anomalies and Chernobyl
58. Evaluation of the impact of Chernobyl on the prevalence of congenital anomalies in 16 regions of Europe
59. The Chernobyl accident, congenital anomalies and other reproductive outcomes
60. Frequency of trisomy 21 in Germany before and after the Chernobyl accident
61. Down syndrome clusters in Germany after the Chernobyl accident
62. Down's syndrome in the Lothian region of Scotland: 1978-89
63. Impact of prenatal diagnosis on revised live birth prevalence estimates of Down syndrome in the Lothian region of Scotland, 1978-92
64. Down syndrome and ionizing radiation