The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes

Chemico-Biological Interactions

Volumn 102, Issue 3, 1996, Pages 169-182

  Bogaards, Jan J P ^a   Venekamp, Joke C ^a   Van Bladeren, Peter J ^a  

^a TNO   (Netherlands)

Author keywords

Cytochrome P 450; Isoprene; Metabolism

Indexed keywords

CYCLOHEXANE OXIDE; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; EPOXIDE HYDROLASE; ISOPRENE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; EPOXIDATION; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; MOUSE; NONHUMAN; RAT; SPECIES DIFFERENCE; XENOBIOTIC METABOLISM;

ANIMALS; BIOTRANSFORMATION; BUTADIENES; CYCLOHEXANES; CYCLOHEXENES; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; HEMITERPENES; HUMANS; HYDROLYSIS; MICE; MICROSOMES, LIVER; OXIDATION-REDUCTION; PENTANES; RATS; RATS, WISTAR; SPECIES SPECIFICITY;

EID: 0030596088     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(96)03741-6     Document Type: Article

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