FUT2 gene involved in expression of H blood group antigen on surface of human tumor cell lines BEL-7404, SGC-7901, and SPC-A-1

Acta Pharmacologica Sinica

Volumn 21, Issue 11, 2000, Pages 997-1001

  Xing, L ^a   Guo, L H ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

ABO antigens; Cultured tumor cells; Fucosyltransferases; FUT2 gene

Indexed keywords

BLOOD GROUP ABH ANTIGEN; FUCOSYLTRANSFERASE;

ANTIGEN EXPRESSION; ARTICLE; BLOOD GROUP ABO SYSTEM; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TUMOR CELL; TUMOR CELL CULTURE;

3T3 CELLS; ABO BLOOD-GROUP SYSTEM; ADENOCARCINOMA; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL MEMBRANE; FUCOSYLTRANSFERASES; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; RNA, MESSENGER; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0033678932     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Molecular cloning, sequence, and expression of a human GDP-L-fucose: β-D-galactoside 2-α-L-fucosyltransferase cDNA that can form the H hood group antigen
2. Reduction of metastatic properties of BL6 melanoma cells expressing terminal fucose αl- 2-galactose after αl, 2-fucosyltransferase cDNA transfection
3. Expression of A and H blood-group and CD44 antigens during chemical rat colonic carcinogenesis
4. Increase of rat colon carcinoma cells tumorigenicity by α(1 - 2) fucosyltransferase gene transfection
5. Increased tumorigenicity of rat colon carcinoma cells after αl, 2-fucosyltransferase FTA antisense cDNA transfection
6. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells
7. Reduction in the level of Gal (αl,3) Gal in transgenic mice and pigs by the expression of an α(1,2) fucosyltransferase
8. Sequence and expression of a candidate for the human secretor blood group (1,2) fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype
9. Quantitation of mRNA by the polymerase chain reaction
10. Adenovirus-mediated expression of human secretor type α(1,2) fucosyltransferase reduces level of Galα (1,3)Gal epitope
11. A new genetic model proposing that the Se gene is a structural gene closely linked to the H gene
12. The presence of at least two different H blood-group-related β-D-Galα-2-L-fucosyltransferases in human serum and the genetics of blood group H substances
13. Molecular cloning of a human genomic region containing the H blood group (1,2) fucosyltransferase gene and two H locus-related DNA restriction fragments, isolation of a candidate for the human secretor blood group locus
14. Structure and expression of the gene encoding secretor-type galactoside 2-α-L-fucosyltransferase (FUT2)
15. Reduction of the major swine xenoantigen, the α-Galactosyl epitope by transfection of the α2,3-Sialyltransferase gene