Mutation screening of interferon regulatory factor 1 gene (IRF-1) as a candidate gene for atopy/asthma

Clinical and Experimental Allergy

Volumn 30, Issue 11, 2000, Pages 1563-1567

  Noguchi, E ^a   Shibasaki, M ^a   Arinami, T ^a   Yamakawa Kobayashi, K ^a   Yokouchi, Y ^a   Takeda, K ^a   Matsui, A ^a   Hamaguchi, H ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Asthma; Atopy; Genetic; IL 4 gene cluster; IRF 1; Polymorphism

Indexed keywords

INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 4;

ALLERGIC ASTHMA; AMINO ACID SUBSTITUTION; ARTICLE; ATOPY; CHROMOSOME 5; CORRELATION FUNCTION; CYTOKINE PRODUCTION; DISEASE COURSE; EXON; GENE CLUSTER; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC SCREENING; HUMAN; JAPAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; TH1 CELL; TH2 CELL;

EID: 0033677519     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00916.x     Document Type: Article

References (35)

1. A family study of the genetic basis of asthma and wheezy bronchitis
2. Genetics of asthma and hay fever in Australian twins
3. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations
4. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population
5. Tumour necrosis factor haplotypes and asthma
6. Evidence for linkage between the development of asthma in childhood and the T-cell receptor beta chain gene in Japanese
7. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q
8. Maternal inheritance of atopic IgE responsiveness on chromosome 11q
9. Association between atopy, and variants of the beta subunit of the high-affinity immunoglobulin E receptor
10. Fc epsilon RI-beta polymorphism and risk of atopy in a general population sample
11. Linkage of high-affinity IgE receptor gene with bronchial hyper-reactivity, even in absence of atopy
12. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations
13. Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study
14. Genetic linkage of T-cell receptor alpha/delta complex to specific IgE responses
15. Germline TCR-A restriction of immunoglobulin E responses to allergen
16. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
17. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma
18. A genome-wide search for quantitative trait loci underlying asthma
19. A genome-wide search for asthma susceptibility loci in ethnically diverse populations
20. Interleukin-4 and interferon-gamma production in atopic and non-atopic children with asthma
21. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects
22. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements
23. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
24. Role of interferon regulatory factor 1 in induction of nitric oxide synthase
25. Nitric oxide and asthmatic inflammation
26. CD4+ T cells from IRF-1-deficient mice exhibit altered patterns of cytokine expression and ceil subset homeostasis
27. Association study of asthma and atopy traits and chromosome 5q cytokine cluster markers
28. Asthma and wheezing in the first six years of life. The Group Health Med Associates
29. Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: Implications for a gene network in the interferon system
30. On measures of genetic disequilibrium
31. Current methods of mutation detection
32. Genetic control of serum IgE levels and asthma: Linkage and linkage disequilibrium studies in an isolated population
33. Association of asthma and the interleukin 4 promoter gene in Japanese