Interaction of ethanol with retinol and retinoic acid in RAR β and GAP-43 expression

Neurotoxicology and Teratology

Volumn 22, Issue 6, 2000, Pages 829-836

  Grummer, Mary A ^a   Zachman, Richard D ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Ethanol; Fetal alcohol syndrome; GAP 43; LAN 5 neuroblastoma cell; Retinoic acid; Retinoic acid receptor

Indexed keywords

ALCOHOL; CYCLOHEXIMIDE; MESSENGER RNA; NEUROMODULIN; RECEPTOR SUBTYPE; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOL;

ALCOHOL INTOXICATION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

BLOTTING, NORTHERN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ETHANOL; GAP-43 PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TRETINOIN; TUMOR CELLS, CULTURED; VITAMIN A;

EID: 0033673446     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(00)00100-8     Document Type: Article

References (56)

1. Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones
2. Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression
3. Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure
4. Interactive dysmorphogenic effects of all-trans retinol and ethanol on cultured whole rat embryos during organogenesis
5. Expression of neurofilament proteins during retinoic acid-induced differentiation of P19 embryonal carcinoma cells
6. Retinoid-regulated gene expression in neural development
7. The fetal alcohol syndrome
8. Modulation by retinoids of mRNA levels of nuclear retinoic acid receptors in murine melanoma cells
9. Retinoic acid synthesis in normal and Alzheimer-diseased brain and human neural cells
10. Temporally regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects
11. A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step
12. Are ethanol-induced birth defects caused by functional retinoic acid deficiency?
13. Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
14. Activation of three distinct RXR/RAR heterodimers induces growth arrest and differentiation of neuroblastoma cells
15. Effect of chronic alcohol consumption and moderate fat diet on vitamin A status in rats fed either vitamin A or β-carotene
16. Effect of chronic ethanol consumption and moderate- or high-fat diet upon tissue distribution of vitamin A in rats fed either vitamin A or β-carotene
17. Maternal ethanol ingestion effects in fetal rat brain vitamin A as a model for fetal alcohol syndrome, FAS
18. The effect of maternal ethanol ingestion on fetal vitamin A in the rat
19. Prenatal ethanol consumption alters the expression of cellular retinol binding protein and retinoic acid receptor mRNA in fetal rat embryo and brain
20. Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA
21. Retinoic acid and dexamethasone affect RAR β and surfactant protein C mRNA in the MLE lung cell line
22. Characterization of the cholinergic neuronal differentiation of the human neuroblastoma cell line LAN-5 after treatment with retinoic acid
23. A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS
24. Genetic analysis of RXR-α developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis
25. The induction of P450-mediated oxidation of all-trans retinoic acid by retinoids in head and neck squamous cell carcinoma cell lines
26. In utero ethanol exposure retards growth and alters morphology of cortical cultures: GM1 reverses effects
27. Alcohol, liver, and nutrition
28. Function of the retinoic acid receptors (RARs) during development: I. Craniofacial and skeletal abnormalities in RAR double mutants
29. Growth factor-mediated neural proliferation: target of ethanol toxicity
30. Retinoids in neural development
31. Vitamin A deficient quail embryos have half a hindbrain and other neural defects
32. The retinoid receptors
33. Targeted disruption of GAP-43 in P19 embryonal carcinoma cells inhibits neuronal differentiation as well as acquisition of the morphological phenotype
34. Function of the retinoic acid receptors (RARs) during development: II. Multiple abnormalities at various stages of organogenesis in RAR double mutants
35. The effects of prenatal exposure to ethanol on cell proliferation and neuronal migration
36. Retinoid receptors, their ligands, and teratogenesis: synergy and specificity of effects
37. Expression of nuclear retinoic acid receptors in wild-type and mutant embryonal carcinoma PCC4.aza1R cells
38. Nuclear retinoid receptors and mechanisms of action
39. Post-transcriptional regulation of GAP-43 gene expression in PC12 cells through protein kinase C-dependent stabilization of the mRNA
40. Induction and tissue-specific expression of rabbit cytochrome P450IIE1 and IIE2 genes
41. Hypothesis: prenatal ethanol-induced birth defects and retinoic acid
42. CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family
43. Reversal of alcohol's effect on neurite extension and on neuronal GAP-43/B50, N-myc, and C-myc protein levels by retinoic acid
44. Transcriptional upregulation of retinoic acid receptor β (RAR β) expression by phenylacetate in human neuroblastoma cells
45. Fetal alcohol syndrome in adolescents and adults
46. Moderate prenatal alcohol exposure: effects on child IQ and learning problems at age 7 1/2 years
47. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43
48. Retinoic acid reverses ethanol-induced cardiovascular abnormalities in quail embryos
49. Effect of ethanol on cytochrome P450 in the rat brain
50. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochrome P450 (CYP26)
51. Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans retinoic acid
52. The regulation of retinoic acid formation
53. Retinoic acid upregulates nuclear retinoic acid receptor-α expression in human neuroblastoma cells
54. Differential susceptibilities of spinal cord neurons to retinoic acid-induced survival and differentiation
55. The interaction of ethanol and vitamin A as a potential mechanism for the pathogenesis of fetal alcohol syndrome