Metallothionein in human atherosclerotic lesions: A scavenger mechanism for reactive oxygen species in the plaque?

Virchows Archiv

Volumn 437, Issue 5, 2000, Pages 528-533

  Göbel, Heike ^a   Van Der Wal, Allard C ^a   Teeling, Peter ^a   Van Der Loos, Chris M ^a   Becker, Anton E ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Immunohistochemistry; Matrix metalloproteinase 9; Metallothionein; Oxidative stress; Smooth muscle cells

Indexed keywords

GELATINASE B; LIPOPROTEIN; METALLOTHIONEIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL TYPE; CONTROLLED STUDY; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MODIFICATION; SMOOTH MUSCLE FIBER;

ARTERIOSCLEROSIS; FREE RADICAL SCAVENGERS; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 9; METALLOTHIONEIN; MICROSCOPY, IMMUNOELECTRON; MUSCLE, SMOOTH, VASCULAR; REACTIVE OXYGEN SPECIES; TISSUE DISTRIBUTION;

EID: 0033672993     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280000260     Document Type: Article

References (46)

1. Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein
2. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry
3. Double immunocytochemical labeling applying the protein A-gold technique
4. Atherosclerosis: Basic mechanisms. Oxidation, inflammation, and genetics
5. Immunofluorescence and immunoenzyme histochemistry
6. 2) increases the steady state mRNA levels of collagenase/MMP1 in human dermal fibroblasts
7. Oxidative stress as a mediator of apoptosis
8. The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein
9. Oxidative stress: The paradox of aerobic life
10. Risk of thrombosis in human atherosclerotic plaques: Role of extracellular lipid, macrophage and smooth muscle content
11. Biochemistry and pathology of radical-mediated protein oxidation
12. Mechanisms of monocyte recruitment and accumulation
13. N-Acetyl-Cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells. New target for antioxidant therapy?
14. Human atherosclerosis: II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions
15. Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids - Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein
16. Significance of metallothionein overexpression in human tumors
17. Metallothionein
18. A novel, simple, reliable and sensitive method for multiple immunoenyzme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens
19. Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation
20. Multiple labeling in electron microscopy: Its application in cardiovascular research
21. High metallothionein expression is associated with features predictive of aggressive behavior in endometrial carcinoma
22. Collagen degradation by superoxide anion in pulse and gamma radiolysis
23. Biological function of metallothionein. V. its induction in rats by various stresses
24. Immunohistochemical expression of metallothionein in invasive breast cancer in relation to proliferative activity, histology and prognosis
25. Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury
26. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metallopoteinases in vitro: Implications for atherosclerotic plaque stability
27. Low levels of reactive oxygen species as modulators of cell function
28. Human atherosclerosis: I. Cell composition and characteristics of advanced lesions of the superficial femoral artery
29. Oxygen free radicals and metallothionein
30. Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis
31. Immunohistochemical expression of metallothionein in normal human colorectal mucosa, in adenomas and in adenocarcinomas and their metastases
32. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein
33. Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis
34. beta-carotene and alpha-tocopherol inhibit the development of atherosclerotic lesions in hypercholesterolemic rabbits
35. Oxidants as stimulators of signal transduction
36. Possible role for metallothionein in protections against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
37. Delineation of human thymocyte differentiation pathways utilizing double-staining techniques with monoclonal antibodies
38. Practical suggestions for successful immunoenzyme double-staining experiments
39. Fibrous and lipid-rich atherosclerotic plaques are part of interchangeable morphologies related to inflammation: A concept
40. Evaluating oxidation processes in relation to cardiovascular disease: A current review of oxidant/antioxidant methodology
41. 2 toxicity
42. Superoxide and peroxynitrite in atherosclerosis
43. Role of oxidised low density lipoprotein in atherogenesis
44. Susceptibility of low-density lipoprotein to oxidative modification
45. The oxidation hypothesis of atherosclerosis
46. Evidence for a local immune response in atherosclerosis CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice