Inhibition of adenosine kinase induces expression of VEGF mRNA and protein in myocardial myoblasts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 5 48-5, 2000, Pages

  Gu, Jian Wei ^a   Ito, Bruce R ^b   Sartin, Amanda ^a   Frascogna, Nan ^a   Moore, Michael ^a   Adair, Thomas H ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b Metabasis Therapeutics Inc   (United States)

Author keywords

Adenosine deaminase; Adenosine receptors; Angiogenesis; Endothelial cells; GP 515; Growth factors; Vascular endothelial growth factor; Vascular maintenance factor

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR; GROWTH FACTOR; M PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HEART CELL CULTURE; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REGULATORY MECHANISM;

EID: 0033672176     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.5.h2116     Document Type: Article

References (52)

1. Does adenosine have a regulatory role in the growth of blood vessels?
2. Growth regulation of the vascular system: Evidence for a metabolic hypothesis
3. Vascular development in chick embryos: A possible role for adenosine
4. Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: Implications for coronary angiogenesis
5. The role of adenosine in the regulation of coronary blood flow
6. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
7. Hypoxia preconditions rabbit myocardium via adenosine and catecholamine release
8. Adenosine receptor subtypes
9. The anti-inflammatory effects of adenosine kinase inhibitor are mediated by adenosine
10. Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release
11. Formation of S-adenosyl-homocysteine in the heart. II. A sensitive index for regional myocardial underperfusion
12. 2
13. Endogenous adenosine inhibits catecholamine contractile responses in normoxic hearts
14. Adenosine inhibits growth of human aortic smooth muscle cells via A(2B) receptors
15. Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth
16. Stimulation of angiogenesis by adenosine on the chick chorioallantoic membrane
17. Protective effects of adenosine in myocardial ischemia
18. Adenosine stimulates proliferation of human endothelial cells in culture
19. Adenosine stimulation of DNA synthesis in human endothelial cells
20. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
21. The biology of vascular endothelial growth factor
22. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins
23. Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine
24. Angiogenesis
25. Adenosine formation during hypoxia in isolated hearts: Effects of adrenergic blockade
26. Hypoxia-induced expression of VEGF is reversible in myocardial vascular smooth muscle cells
27. Adenosine upregulates VEGF expression in cultured myocardial vascular smooth muscle cells
28. Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia
29. Adenosine formation and myocardial energy status during graded hypoxia
30. Myocardial adenosine formation during hypoxia: Effects of ecto-5'-nucleotidase inhibition
31. 31P-NMR study in isolated rat heart
32. 5'-Nucleotidase and adenosine deaminase activities in blood of patients with unstable angina pectoris
33. Rapid turnover of the AMP-adenosine metabolic systole in the guinea pig heart
34. Receptor-mediated and metabolic effects of adenosine in ischemic and postischemic myocardium
35. 14C into rabbit heart adenine nucleotides
36. Mechanisms leading to adenosine-stimulated proliferation of microvascular endothelial cells
37. Adenosine and hypoxia stimulate proliferation and migration of endothelial cells
38. Uptake of adenosine by dispersed chick embryonic cardiac cells
39. Interaction of β-adrenoceptor and adenosine receptor agonists on phosphorylation: Identification of target proteins in mammalian ventricles
40. Measurement of adenosine, inosine and hypoxanthine in human plasma
41. Incorporation of analog purine nucleosides into the formed elements of human blood: Erythrocytes, platelets, and lymphocytes
42. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
43. Regulation of adenosine formation by the heart
44. Adenosine: A homeostatic metabolite in cardiac energy metabolism
45. Quantitatire relation between interstitial adenosine concentration and coronary blood flow
46. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells
47. Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia
48. Adenosine nucleotides, adenosine and adenine as angiogenesis factors
49. Cloned receptors and cardiovascular responses to adenosine
50. Vascular endothelial growth factor augments muscle blood flow and function in a rabbit model of chronic hindlimb ischemia
51. Uptake and metabolism of purine nucleosides and nucleotides in isolated frog skeletal muscle
52. Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor