Insulin-like growth factor-I (IGF-I) protects myelination from undernutritional insult: Studies of transgenic mice overexpressing IGF-I in brain

Journal of Neuroscience Research

Volumn 62, Issue 5, 2000, Pages 700-708

  Ye, Ping ^a   Kee Hyoung, Lee ^b   D'Ercole, A Joseph ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Korea University College of Medicine   (South Korea)

Author keywords

IGF I; MBP; Myelination; Oligodendrocyte; PLP; Precursors; Undernutrition

Indexed keywords

MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; CORPUS CALLOSUM; GENE EXPRESSION REGULATION; MALNUTRITION; MOUSE; MYELINATION; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN; CELL COUNT; CEREBRAL CORTEX; CORPUS CALLOSUM; FOOD DEPRIVATION; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; MYELIN PROTEINS; MYELIN PROTEOLIPID PROTEIN; OLIGODENDROGLIA; RNA, MESSENGER;

EID: 0033670607     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001201)62:5<700::AID-JNR9>3.0.CO;2-1     Document Type: Article

References (38)

1. Estimation of nuclear poplation from microtome sections
2. Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain
3. Cell death and control of cell survival in the oligodendrocyte lineage
4. Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development
5. Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons
6. Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
7. Biochemical and morphometric analysis show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition
8. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
9. Nutritional regulation of IGF-I and IGF binding proteins
10. p1B15: A cDNA clone of the rat mRNA encoding cyclophilin
11. Brain growth retardation due to the expression of human insulin-like growth factor binding protein-1 (IGFBP-1) in transgenic mice: An invivo model for the analysis of IGF function in the brain
12. Differential growth recovery within the brains of postnatally undernourished rats
13. The relationship between nutritional adequacy and brain myelin accumlation: A comparison of varying degrees of well fed and undernourished rats
14. In vivo effects of insulin-like growth factor-I on the development of sensory pathway: Analysis of the primary somatic sensory cortex (S1) of transgenic mice
15. Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse
16. Sequence of cDNA encoding human insulin-like growth factor I precursor
17. Assembly of CNS myelin in the absence of proteolipid protein
18. Effects of undernutrition on gliogenesis and glial maturation in rat corpus callosum
19. Insulin-like growth factor-I (IGF-I) ameliorates and IGF binding protein-1 (IGFBP-1) exacerbates the effects of undernutrition on brain growth during early postnatal life: Studies in IGF-I and IGFBP-1 transgenic mice
20. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor
21. Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding
22. Insulin-like growth factor-I inhibits mature oligodendrocyte apoptosis during primary demyelination
23. Insulin-like growth factor I/somatomedin C: A potent inducer of oligodendrocyte development
24. Identification of a cDNA coding for a fifth form of myelin basic protein in mouse
25. Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF-I binding protein-1
26. Co-localization of NG2 proteoglycan and PDGFα-receptor on O2A progenitor cells in the developing rat brain
27. + glial cells are distinct from resting and activated microglia
28. Differential expression of insulin-like growth factor genes in rat central nervous system
29. Down regulation of myelin-specific mRNAs in the mechanism of hypomyelination in the undernourished developing brain
30. Differential effects of protein-calorie restriction and subsequent repletion on neuronal and nonneuronal components of cerebral cortex in newborn rats
31. The relative numbers of oligodendroglia in different brain regions of normal and postnatally undernourished rats
32. Myelination: Acritical stage in development
33. Cellular response in rat during malnutrition at various age
34. Insulin-like growth factor I protects oligodendrocytes from tumor necrosis factor-α-induced injury
35. Cyclic AMP-induced upregulation of proteolipid protein and myelin associated glycoprotein gene expression in C6 cells
36. In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: Studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice
37. Insulin-like growth factor-I influences the initiation of myelinadon: Studies of the anterior commissure of transgenic mice
38. Regulation of insulin-like growth factor-I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene