Soy-derived antiapoptotic fractions protect gastrointestinal epithelium from damage caused by methotrexate treatment in the rat

Nutrition and Cancer

Volumn 33, Issue 1, 1999, Pages 33-39

  Logvinova, Anna V ^a   Foehr, Matthew W ^a   Pemberton, Philip A ^a   Khazalpour, K Michael ^a   Funk Archuleta, Martha A ^b,c   Bathurst, Ian C ^a   Tomei, L David ^a  

^a LXR Biotechnology Inc   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF IDAHO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN; METHOTREXATE; SOYBEAN PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; GASTROINTESTINAL TOXICITY; INFLAMMATION; INTESTINE NECROSIS; MALE; MITOSIS RATE; MOUSE; NONHUMAN; RAT;

EID: 0033006981     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635589909514745     Document Type: Article

References (19)

1. Funk-Archuleta, MA, Foehr, MW, Tomei, LD, Hennebold, KL, and Bathurst, IC: A soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat. Nutr Cancer 29, 217-221, 1997.
2. Zeaman, FJ: Nutrition and cancer. In Clinical Nutrition and Dietetics, 2nd ed. New York: Macmillan, 1991, pp 571-598.
3. Pinkerton, CR, and Millia, PJ: Methotrexate enterotoxicity: influence of drug dose and riming in the rat. Br J Cancer 49, 97-101, 1984.
4. Craft, JW, Hem, K, Lawson, DN, and MacElwain, TJ: Methotrexate-induced malabsorption in children with acute lymphoblasn'c leukemia. Br Med J 2, 1511-1512, 1977.
5. Pinkerton, CR, Cameron, CHS, Sloan, JM, Glasgow, JFT, and Gevara, NFT: Jejunal crypt cell abnormalities, associated with methotrexate treatment in children with acute lymphoblastic leukemia. J Clin Pathol 35, 1272-1277, 1982.
6. Cunningham, D, Morgan, RJ, Mill, PR, Toukop, M, and McArdle, CS: Functional and structural changes of the human proximal small intestine after cytotoxic therapy. J Clin Pathol 38, 265-270, 1985.
7. 51Cr-EDTA in rats with experimentally induced enteropathy. Gut 26, 579-585, 1985.
8. Mitchell, EP, and Schein, PS: Gastrointestinal toxicity of chemotherapeutic agents. In Toxicity of Chemotherapy. New York: Grune & Stratton, 1984, pp 269-295.
9. Chevreau, N, and Funk-Archuleta, M: Effect of enteral formulas on methotrexate toxicity. Nutr Cancer 23, 185-204, 1995.
10. Funk, MA, and Baker, DH: Effect of soy products on methotrexate toxicity in rats. J Nutr 121, 1684-1692, 1991.
11. Funk, MA, and Baker, DH: Effect of fiber, protein source and time of feeding on methotrexate toxicity in rats. J Nutr 121, 1673-1683, 1987.
12. Barry, MA, Behnke, CA, and Eastman, A: Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 40, 2353-2362, 1990.
13. Tomei, LD, Shapiro, JP, and Cope, FO: Apoptosis in C3H10T1/2 mouse emryonic cells: evidence for internucleosomal DNA modification in the absence of double strand cleavage. Proc Natl Acad Sci USA 90, 853-857, 1993.
14. Cope, FO, Issinger, OG, McArdle, AH, Shapiro, JP, and Tomei, LD: Enteral peptide formulas inhibit radiation induced enteritis and apoptosis in intestinal cells and suppress the expression and function of Alzheimer and cell division control gene products (abstr). FASEB J 5, A931, 1991.
15. Abramovitz, AS, Yavelow, J. Randolf, V, and Troll, W: Inhibition of superoxide production in human neutrophils by purified soybean polypeptide. Reevaluation of the involvement of proteases. J Biol Chem 258, 15153-15157, 1983.
16. Current Methods of Molecular Biology. New York: Wiley, 1996, vol 2, sect 14-1.
17. Robinson, JWL, Antonioli, J-A, and Vanotti, A: The effect of oral methotrexate on the rat intestine. Biomed Pharmacol 15, 1479-1489, 1966.
18. Oats, PS, Morgan, RG, and Light, AM: Cell death (apoptosis) during pancreatic involution after soya flour feeding in the rat. Am J Physiol 250, G9-G14, 1986.
19. Weil, MM, Stephens, LC, Amos, CI, Ruifrok, AC, and Mason, KA: Strain difference in jejunal crypt cell susceptibility to radiation-induced apoptosis. Int J Radiat Biol 70, 579-585, 1996.