Inverse correlation between Ink4-locus deletions and ICM-DNA hyperdiploidy in childhood acute lymphoblastic leukaemia, relation to clinical characteristics and outcome

European Journal of Haematology

Volumn 65, Issue 6, 2000, Pages 390-398

  Calero, T ^a   Widell, S ^b   Czader, M ^c   Grander D ^a   Soderhall S ^c   Gustafsson, G ^c   Einhorn, S ^a   Porwit, A ^c   Heyman, M ^a,c  

^a Department of General Oncology   (Sweden)

^b Division of Cellular and Molecular Tumour Pathology   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Childhood ALL; DNA index; Image DNA cytometry; p14ARF; p16ink4a; Prognosis

Indexed keywords

DNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ALLELE; ARTICLE; CANCER CELL; CELL CYCLE; CHILD; CONTROLLED STUDY; CORRELATION FUNCTION; DIPLOIDY; DNA CONTENT; FEMALE; GENE DELETION; GENE LOCUS; HUMAN; HUMAN CELL; IMAGE CYTOMETRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS;

ACTUARIAL ANALYSIS; ADOLESCENT; BLOTTING, SOUTHERN; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHILD; CHILD, PRESCHOOL; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOGENETIC ANALYSIS; DIPLOIDY; DISEASE-FREE SURVIVAL; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENES, CDC; GENES, TUMOR SUPPRESSOR; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; MULTIGENE FAMILY; PHENOTYPE; RISK FACTORS; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEINS;

EID: 0033665801     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2000.065006390.x     Document Type: Article

References (43)

1. Treatment of childhood leukemias
2. Philadelphia chromosome positive childhood acute lymphoblastic leukamia: Clinical and cytogenetic characteristics and treatment outcome
3. Prognostic and biological importance of chromosome findings in acute lymphoblastic leukemia
4. Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with near haploid and hypodiploid <45 line
5. Biology and clinical significance of cytogenetics abnormalities in childhhod ALL
6. The importance of blast cell DNA content for prognosis of childhood acute lymphoblastic leukemia
7. DNA aneuploidy in childhood acute lymphoblastic leukemia: Relation to clinical determinants and prognosis within four consecutive BFM trials
8. Prognostic importance of blasts cell DNA content in childhood acute lymphoblastic leukemia
9. Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell ALL of childhood: A Pediatric Oncology Group study
10. Tel/Aml1 fusion resulting from a cryptic t(12-21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis
11. 12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia
12. Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features
13. Prognostic importance of p15INK4B and p16INK4A gene inactivation in childhood acute lymphoblastic leukemia
14. Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood
15. Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: Results of St Jude Total Therapy Study XII
16. Incidence and clinical significance of CDKN2/MTS1/p16INK4A and MTS2/p15INK4B gene deletions in childhood acute lymphoblastic leukemia
17. Homozygous deletions of the p16/MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome
18. Inverse correlation bet-ween loss of heterozygosity of the short arm of chromosome 12 and p15ink4b/p16ink4a gene inactivation in childhood acute lymphoblastic leukaemia
19. Proposals for the classification of the acute leukaemias
20. Immunology of leukemia
21. Intensified treatment of acute lymphoblastic leukemia has improved prognosis, especially in non-high-risk patients: The Nordic experience of 2648 patients diagnosed between 1981 and 1996
22. Inhibition of human NK cell activity by induction of cyclic AMP depends on impaired target cell recognition
23. Deletion of α-, -β and ω-IFN genes in malignant cells from children with acute lymphoblastic leukemia
24. p15ink4b and p16ink4a gene inactivation in acute lymphoblastic leukemia
25. Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells
26. DNA rearrangements in human follicular lymphoma can involve the 5' or 3' region of the bcl-2 gene
27. An additional breakpoint region in the bcl-1 locus associated with the t(11;14)-(q14;q32) translocation of chronic lymphocytic leukemia
28. The gene for familial polyposis coli maps to the long arm of chromosome 5
29. Cytophotometry
30. DNA image analysis in childhood acute lymphoblastic leukemia
31. Convention on nomenclature for DNA cytometry
32. Optical microscope system for standarized cell measurements and analysis
33. Methodological aspects of DNA image cytometry in normal bone marrow smears
34. DNA image cytometry in MDS bone marrow smears
35. A prospective comparison of DNA quantitation by image and flow cytometry
36. Comparison of acute myeloid leukemia occurring de novo or preceded by a myelodysplastic stage: Differences in cellular DNA content
37. Variation in DNA content of immature normal bone marrow cells
38. Hyperdiploid acute lymphoblastic leukemia with 51 to 65 chromosomes: A distinct biological entity with a marked propensity to undergo apoptosis
39. Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisae
40. Reversible, p16 mediated cell cycle arresr as protection from chemotherapy
41. Increase in radiation sensitivity of human malignant melanoma cells by expression of wild-type p16 gene