Effect of P-glycoprotein modulators on alkaline phosphatase activity in cultured rat hepatocytes

Cellular Physiology and Biochemistry

Volumn 10, Issue 4, 2000, Pages 195-202

  Calhau, Conceição ^a   Martel, Fatima ^a   Hipólito Reis, Candido ^a   Azevedo, Isabel ^a  

^a Inst of Pharmacol and Therapeutics   (Portugal)

Author keywords

Alkaline phosphatase; Organic cation transporter; P glycoprotein; Rat hepatocytes

Indexed keywords

4 NITROPHENOL; 4 NITROPHENYL PHOSPHATE; ALKALINE PHOSPHATASE; CORTICOSTERONE; CYCLOSPORIN A; DAUNORUBICIN; GENISTEIN; GLYCOPROTEIN P; KAEMPFEROL; LEVAMISOLE; OCTREOTIDE; VANADIC ACID; VERAPAMIL;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 0033661528     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016350     Document Type: Article

References (46)

1. Interpretation and clinical significance of alkaline phosphatase isoenzyme patterns
2. Alkaline phosphatase and exchange surfaces
3. 3 H]-1-phenylpyridinium in rat isolated hepatocytes: Putative involvement of a P-glycoprotein transporter
4. Postnatal development of organic cation transport in the rat liver
5. 3 H]-adrenaline by freshly isolated rat hepatocytes: Putative involvement of P-glycoprotein
6. Distribution of alkaline phosphatase activity in healthy and diseased human liver tissue
7. Rat liver alkaline phosphatases. Evidence hepatocyte and portal triad enzymes differ
8. Biochemistry of multidrug resistance mediated by the multidrug transporter
9. Modulation of drug permeability in Chinese hamster ovary cells. Possible role for phosphorylation of surface glycoproteins
10. Differential modulation of P-glycoprotein transport by protein kinase inhibition
11. Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes
12. Role of organic cation transporters in drug absorption and elimination
13. + in cultured rat hepatocytes
14. Comparison between uptake2 and rOCT1: Effect of catecholamines, metanephrines and corticosterone
15. Effect of fat feeding on intestinal alkaline phosphatase activity in tissue and serum
16. Secretion and distribution of rat intestinal surfactant-like particles after fat feeding
17. Synthesis and parallel secretion of rat intestinal alkaline phosphatase and surfactant-like particle protein
18. A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
19. The extraneuronal uptake and metabolism of cathecolamines
20. Relationship between the inhibition constants (k(i)) and the concentration which causes 50% inhibition of enzymatic reaction
21. Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein
22. Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine
23. Induction of multidrug resistance gene expression in rat liver cells in response to acute treatment by the DNA-damaging agent methyl methanesulfonate
24. Cyclosporin inhibits phosphate transport and stimulates alkaline phosphatase activity in renal BBMV
25. Cyclosporin in cadaveric renal transplantation: 5-year follow-up of a multicentre trial
26. Verapamil increases serum alkaline phosphatase in hypertensive patients
27. Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: The genistein effect is enhanced by zinc
28. Zinc enhancement of genistein's anabolic effect on bone components in elderly female rats
29. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation
30. Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein
31. Somatostatin: The neuroendocrine story
32. Characterization of a membrane tyrosine phosphatase in AR42J cells: Regulation by somatostatin
33. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: Mediation by human somatostatin receptor subtypes SSTR1 and SSTR2
34. Somatostatin inhibits AP-1 function via multiple protein phosphatases
35. Modified somatostatins as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes
36. Hepatocellular transport of cyclosomatostatins: Evidence for a carrier system related to the multispecific bile acid transporter
37. Characterization of the transport of a cationic octapeptide, octreotide, in rat bile canalicular membrane: Possible involvement of P-glycoprotein
38. Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase
39. P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid
40. Phosphotyrosyl protein phosphatases
41. Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart
42. Increase of alkaline phosphatase in multidrug-resistant tumor cells and their cross-resistance to 6-thioguanine
43. Antiestrogens and steroid hormones: Substrates of the human P-glycoprotein
44. Effects of steroids and verapamil on P-glycoprotein ATPase activity: Progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators