Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats. 17) Testicular toxicity of e7010, a sulfonamide tubulin polymerization inhibitor

Journal of Toxicological Sciences

Volumn 25, Issue SPEC. ISS, 2000, Pages 173-178

  Hayakawa, K ^a   Tashiro, T ^a   Sato, K ^a   Katsurayama, T ^a   Imai, T ^a   Hosokawa, S ^a   Sagami, F ^a  

^a EISAI CO LTD   (Japan)

Author keywords

E7010; Histopathology; Quantitative morphometry; Rats; Testicular toxicity; TUNEL method

Indexed keywords

ANTINEOPLASTIC AGENT; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; SULFONAMIDE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; MALE; MALE GENITAL SYSTEM; MEIOSIS; MICROTUBULE ASSEMBLY; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE EPITHELIUM; SPERMATOCYTE; SPERMATOGENESIS; TESTIS; TOXICITY TESTING;

ANIMALIA;

EID: 0033660064     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.25.specialissue_173     Document Type: Article

References (14)

1. Properties of sufficiency and statistical tests
2. A multiple comparison procedure for comparing several treatments with a control
3. Aspects of testicular toxicity induced by anticancer drugs
4. Statistics for toxicologists
5. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
6. Morphological changes produced in rats by anticancer drags
7. In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors
8. Effects of repeated doses of compound E for 4 and 9 weeks on the male reproductive organs
9. Toxic and mutagenic influences on spermatogenesis
10. Quantitative studies on spermatogenesis in the albino rat. II. The duration of spermatogenesis and some effects of colchicine
11. Short-time effects of taxol on the seminiferous epithelium of the rat
12. A multiple comparison rank sum test: Treatments versus control
13. Toxicity studies of VP 16-213 (IV) Intravenous one-month subacute toxicity in rats
14. Mechanism of action of E7010, an orally active sulfonamide antitumor agent: Inhibition of mitosis by binding to the colchicine site of tubulin