Free radical intermediates in isolated rat heart during perfusion, ischemia and reperfusion: Effect of ischemic preconditioning

Experimental and Clinical Cardiology

Volumn 5, Issue 2, 2000, Pages 59-64

  Timoshin, A A ^a   Pisarenko, O I ^a   Lakomkin, V L ^a   Studneva, I M ^a   Ruuge, E K ^a  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

Author keywords

Electron paramagnetic resonance; Flavosemiquinone; Ischemic preconditioning; Metabolism; Rat heart; Ubisemiquinone

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE; CREATINE PHOSPHATE; FREE RADICAL; LACTIC ACID; OXYGEN RADICAL; SEMIQUINONE; UBIQUINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENERGY; HEART INFARCTION PREVENTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE PERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PROTEIN EXPRESSION; RAT;

EID: 0033653145     PISSN: 12056626     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
2. Can ischemic preconditioning protect against hypoxia-induced damage? Studies of contractile function in isolated perfused rat hearts
3. Preconditioning induced protection against post-ischaemic contractile dysfunction: Characteristics and mechanisms
4. The role of oxygen free radicals in preconditioning
5. Preconditioning of human myocardium with adenosine during coronary angioplasty
6. Preconditioning in human myocardium
7. Ischaemic preconditioning and contractile function: Studies with normothermic and hypothermic global ischaemia
8. Preconditioning: State of the art myocardial protection
9. Brief cardiac ischemia induces expression of heart shock protein 70
10. Molecular adaptation of cellular defences following preconditioning of the heart by repeated ischaemia
11. +-channel in mediating the effects of acetylcholine to mimic preconditioning in dogs
12. Effects of preconditioning on reperfusion arrhythmias, myocardial functions, formation of free radicals, and ion shifts in isolated ischemic/reperfused rat hearts
13. .- generation and prevents respiratory impairment in the mitochondria of post-ischemic reperfused heart of rat
14. Molecular and cellular mechanisms of myocardial stunning
15. Bradykinin mediates myocardial ischaemic preconditioning against free radical injury in guinea-pig isolated heart
16. Preconditioning of rat heart with monophosphoryl lipid A: A role for nitric oxide
17. Oxygen-derived free radicals and myocardial reperfusion injury: An overview
18. Oxygen radicals can induce preconditioning in rabbit hearts
19. Preconditioning with ischemia: Is the protective effect mediated by free radical induced myocardium stunning?
20. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium
21. N-2-Mercaptopropionyl glycine attenuates infarct size limiting effect of ischemic preconditioning
22. Detection of superoxide radicals in intact heart mitochondria by spin trapping
23. Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow
24. Free radical metabolites in myocardium during ischemia and reperfusion
25. Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox copule with molecular oxygen
26. Free radical centers in isolated rat heart tissue in a normal state, in ischemia, and reperfusion
27. Free radical centers in isolated rat myocardium during perfusion with the normally oxygenated substrate-free solution
28. 10 in mitochondrial respiratory chain and oxygen-derived free radical generation in cardiac cells
29. Untersuchungen am uberlebenden Saugetierherz
30. Comparisons of ESR and HPLC methods for the detection of OH· radicals in ischemic/reperfused hearts. A relationship between the genesis of free radicals and reperfusion arrhythmias
31. ESR studies of the coenzyme Q semiquinone in submitochondrial particles from beef heart
32. EPR spectroscopy of components of the mitochondrial electron-transfer system
33. Myocardial ischemia and reperfusion: Direct evidence for free radical generation by electron spin resonance spectroscopy
34. Direct measurement of free radical generation following reperfusion of ischemic myocradium
35. Ischemic contracture of the myocardium: Mechanism and prevention
36. Relationships between pre-ischemic ATP and glycogen content and post-ischemic recovery of rat heart
37. Opposing facets of ischemic preconditioning? Dichotomy of interpretation with ischemic contracture versus post-ischemic functional recovery
38. Prolonged depletion of ATP and the adenine nucleotide pool due to delayed resynthesis of adenine nucleotides following reversible myocardialischemic injury in dogs
39. Metabolic effects of ischemic preconditioning and adenosine receptor blockade in dogs
40. Preconditioning with a single short episode of global ischemia in the isolated working rat heart: Effect on structure, mechanical function, and energy metabolism for various durations of sustained global ischemia
41. Electron spin resonance measurement on ubiquinone-depleted and ubiquinone-replenished submitochondrial particles
42. EPR studies of flavoprotein radicals
43. Ubisemiquinone in the respiratory chain of heart mitochondria
44. Sublethal ischemia alters myocardial antioxidant activity in canine heart
45. Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes