Characterisation of tolbutamide hydroxylase activity in the common brushtail possum, (Trichosurus vulpecula) and koala (Phascolarctos cinereus): Inhibition by the Eucalyptus terpene 1,8-cineole

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 127, Issue 3, 2000, Pages 351-357

  Liapis, Panagiota ^a   Pass, Georgia J ^b   McKinnon, Ross A ^a   Stupans, Ieva ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Brushtail possum; Cytochrome P450; Eucalyptus; Induction; Koala; Terpenes; Tolbutamide hydroxylation

Indexed keywords

4 METHYLPYRAZOLE; ALPHA NAPHTHOFLAVONE; CINEOLE; CYTOCHROME P450 ISOENZYME; FURAFYLLINE; OXYGENASE; QUINIDINE; SULFAPHENAZOLE; TERPENE; TOLBUTAMIDE; TROLEANDOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEAR; COMPETITIVE INHIBITION; CONTROLLED STUDY; DETOXIFICATION; DIET; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; EUCALYPTUS; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CYCLOHEXANOLS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; EUCALYPTUS; HYPOGLYCEMIC AGENTS; KINETICS; MARSUPIALIA; MENTHOL; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MONOTERPENES; OPOSSUMS; PLANTS, MEDICINAL; RATS; TERPENES; TOLBUTAMIDE;

EID: 0033635699     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(00)00163-8     Document Type: Article

References (16)

1. Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450
2. A host-inducible cytochrome P-450 from a host-specific caterpillar: Molecular cloning and evolution
3. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes
4. Biochemistry and molecular biology of the human CYP2C subfamily
5. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species
6. Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: Simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography
7. Characterization of CYP2C19 and CYP2C9 from human liver: Respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations
8. Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes
9. Induction of xenobiotic metabolising enzymes in the comon brushtail possum, Trichosurus vulpecula, by Eucalyptus terpenes
10. Eucalyptus oil poisoning
11. Biotransformation of mestranol to ethinyl estradiol in vitro: The role of cytochrome P-450 2C9 and metabolic inhibitors
12. Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450
13. Eucalyptus oil: 14 Cases of exposure
14. Hepatic microsomal enzyme activity in the koala and tammar wallaby: High 17β-hydroxysteroid oxidoreductase activity in koala liver microsomes
15. The inhibition of drug oxidation by anhydroerythromycin, an acid degradation product of erythromycin
16. Eucalyptus oil poisoning in childhood: 41 Cases in southeast Queensland