25-dehydro-1α-hydroxyvitamin D3-26,23S-lactone antagonizes the nuclear vitamin D receptor by mediating a unique noncovalent conformational change

Molecular Endocrinology

Volumn 14, Issue 11, 2000, Pages 1788-1796

  Bula, C M ^a   Bishop, J E ^a   Ishizuka, S ^a   Norman, A W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 DEHYDRO 1ALPHA HYDROXYVITAMIN D3 26,23 LACTONE; OSTEOCALCIN; PROTEINASE; SECOSTEROID; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; 22 (3 (DIMETHYLHYDROXYMETHYL)PHENYL) 23,24,25,26,27 PENTANOR 1 HYDROXYVITAMIN D3; 22-(3-(DIMETHYLHYDROXYMETHYL)PHENYL)-23,24,25,26,27-PENTANOR-1-HYDROXYVITAMIN D3; 9,10 SECOCHOLESTA 5,7,10(19),16 TETRAEN 23 YNE 1,3,25 TRIOL; CALCITRIOL; CALCITRIOL RECEPTOR; DRUG DERIVATIVE; HYDROXYCOLECALCIFEROL; RO 23-7553; TEI 9647; VITAMIN D;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG MECHANISM; HORMONAL REGULATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BINDING COMPETITION; BINDING SITE; CHEMISTRY; CHICKEN; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; PROTEIN CONFORMATION; TRANSACTIVATION;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CALCITRIOL; CHICKENS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXYCHOLECALCIFEROLS; OSTEOCALCIN; PROTEIN CONFORMATION; RECEPTORS, CALCITRIOL; RESPONSE ELEMENTS; TRANS-ACTIVATION (GENETICS); VITAMIN D;

EID: 0033625818     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.11.0552     Document Type: Article

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